Human Gene ASNSD1 (uc002uqt.3) Description and Page Index
  Description: Homo sapiens asparagine synthetase domain containing 1 (ASNSD1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:190,526,125-190,535,557 Size: 9,433 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr2:190,530,859-190,535,452 Size: 4,594 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:190,526,125-190,535,557)mRNA (may differ from genome)Protein (643 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ASND1_HUMAN
DESCRIPTION: RecName: Full=Asparagine synthetase domain-containing protein 1; AltName: Full=HCV NS3-transactivated protein 1;
SIMILARITY: Contains 1 asparagine synthetase domain.
SIMILARITY: Contains 1 glutamine amidotransferase type-2 domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.10 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 710.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.20434-0.293 Picture PostScript Text
3' UTR -14.10105-0.134 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001962 - Asn_synthase
IPR017932 - GATase_2_dom
IPR000583 - GATase_dom
IPR014729 - Rossmann-like_a/b/a_fold

Pfam Domains:
PF00733 - Asparagine synthase

SCOP Domains:
52402 - Adenine nucleotide alpha hydrolases-like
56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)

ModBase Predicted Comparative 3D Structure on Q9NWL6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  EnsemblFlyBaseWormBaseSGD
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence
  AlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
GO:0042803 protein homodimerization activity

Biological Process:
GO:0006529 asparagine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0008150 biological_process
GO:0008652 cellular amino acid biosynthetic process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  AK000759 - Homo sapiens cDNA FLJ20752 fis, clone HEP02921.
BC001243 - Homo sapiens asparagine synthetase domain containing 1, mRNA (cDNA clone MGC:4948 IMAGE:3453136), complete cds.
JD465018 - Sequence 446042 from Patent EP1572962.
JD057328 - Sequence 38352 from Patent EP1572962.
JD061683 - Sequence 42707 from Patent EP1572962.
JD316560 - Sequence 297584 from Patent EP1572962.
JD260272 - Sequence 241296 from Patent EP1572962.
AY116969 - Homo sapiens HCV NS3-transactivated protein 1 (NS3TP1) mRNA, complete cds.
AB075481 - Homo sapiens neuroblastoma cDNA, clone:Nbla00058, full insert sequence.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
ASPARAGINE-BIOSYNTHESIS - asparagine biosynthesis I

-  Other Names for This Gene
  Alternate Gene Symbols: ASND1_HUMAN, D3DPH6, Nbla00058, NM_019048, NP_061921, NS3TP1, Q3LIC3, Q4ZG45, Q9NWL6
UCSC ID: uc002uqt.3
RefSeq Accession: NM_019048
Protein: Q9NWL6 (aka ASND1_HUMAN)
CCDS: CCDS2300.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_019048.2
exon count: 6CDS single in 3' UTR: no RNA size: 2487
ORF size: 1932CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 3761.50frame shift in genome: no % Coverage: 99.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.