ID:NADAP_HUMAN DESCRIPTION: RecName: Full=Kanadaptin; AltName: Full=Human lung cancer oncogene 3 protein; Short=HLC-3; AltName: Full=Kidney anion exchanger adapter protein; AltName: Full=Solute carrier family 4 anion exchanger member 1 adapter protein; INTERACTION: Q13418:ILK; NbExp=8; IntAct=EBI-1999704, EBI-747644; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly nuclear. Small amounts are found in the cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 FHA domain. CAUTION: PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking. SEQUENCE CAUTION: Sequence=AAN12269.1; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=Band 3 entry; URL="http://en.wikipedia.org/wiki/Band_3";
Genetic Association Studies of Complex Diseases and Disorders
Alzheimer Disease Mark W Logue et al. Archives of neurology 2011, A comprehensive genetic association study of Alzheimer disease in African Americans., Archives of neurology.
Some genes contribute to AD pathogenesis in both white and African American cohorts, although it is unclear whether the causal variants are the same. A larger African American sample will be needed to confirm novel gene associations, which may be population specific.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BWU0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.