Human Gene KAT5 (uc001ofk.3) Description and Page Index
  Description: Homo sapiens K(lysine) acetyltransferase 5 (KAT5), transcript variant 1, mRNA.
RefSeq Summary (NM_182710): The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr11:65,479,473-65,487,077 Size: 7,605 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr11:65,479,739-65,486,652 Size: 6,914 Coding Exon Count: 13 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:65,479,473-65,487,077)mRNA (may differ from genome)Protein (546 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIOMIM
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: KAT5
Diseases sorted by gene-association score: hiv-1 (14)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.33 RPKM in Testis
Total median expression: 700.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -116.71266-0.439 Picture PostScript Text
3' UTR -180.79425-0.425 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF01853 - MOZ/SAS family
PF11717 - RNA binding activity-knot of a chromodomain

SCOP Domains:
55729 - Acyl-CoA N-acyltransferases (Nat)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q92993-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AK313297 - Homo sapiens cDNA, FLJ93809, highly similar to Homo sapiens HIV-1 Tat interactive protein, 60kDa (HTATIP), mRNA.
U74667 - Human tat interactive protein (TIP60) mRNA, complete cds.
AK225100 - Homo sapiens mRNA for HIV-1 Tat interactive protein, 60kDa isoform 3 variant, clone: CAS07011.
AK226002 - Homo sapiens mRNA for HIV-1 Tat interactive protein, 60kDa isoform 3 variant, clone: FCC109C07.
LF211172 - JP 2014500723-A/18675: Polycomb-Associated Non-Coding RNAs.
JD487598 - Sequence 468622 from Patent EP1572962.
BC117167 - Homo sapiens K(lysine) acetyltransferase 5, mRNA (cDNA clone MGC:150776 IMAGE:40125718), complete cds.
BC143290 - Homo sapiens cDNA clone IMAGE:9051793, containing frame-shift errors.
BC143296 - Homo sapiens K(lysine) acetyltransferase 5, mRNA (cDNA clone MGC:176817 IMAGE:9051800), complete cds.
JD143399 - Sequence 124423 from Patent EP1572962.
LF344393 - JP 2014500723-A/151896: Polycomb-Associated Non-Coding RNAs.
BC093032 - Homo sapiens K(lysine) acetyltransferase 5, mRNA (cDNA clone MGC:110937 IMAGE:30335942), complete cds.
AK304664 - Homo sapiens cDNA FLJ56211 complete cds, highly similar to Histone acetyltransferase HTATIP (EC 2.3.1.48).
BC064912 - Homo sapiens K(lysine) acetyltransferase 5, mRNA (cDNA clone MGC:70769 IMAGE:6067575), complete cds.
U67734 - Human cPLA2 interacting protein mRNA, complete cds.
AB463743 - Synthetic construct DNA, clone: pF1KB8185, Homo sapiens HTATIP gene for HIV-1 Tat interacting protein, 60kDa, without stop codon, in Flexi system.
HQ258620 - Synthetic construct Homo sapiens clone IMAGE:100073169 K(lysine) acetyltransferase 5 (KAT5), transcript variant 2 (KAT5) gene, encodes complete protein.
KJ893065 - Synthetic construct Homo sapiens clone ccsbBroadEn_02459 KAT5 gene, encodes complete protein.
LF214056 - JP 2014500723-A/21559: Polycomb-Associated Non-Coding RNAs.
BC013211 - Homo sapiens K(lysine) acetyltransferase 5, mRNA (cDNA clone IMAGE:4179558).
BC000166 - Homo sapiens K(lysine) acetyltransferase 5, mRNA (cDNA clone IMAGE:2901054), partial cds.
U40989 - Human tat interactive protein mRNA, complete cds.
AB209813 - Homo sapiens mRNA for HIV-1 Tat interactive protein, 60kDa isoform 3 variant protein.
LF344392 - JP 2014500723-A/151895: Polycomb-Associated Non-Coding RNAs.
AK130717 - Homo sapiens cDNA FLJ27207 fis, clone SYN03447, highly similar to Homo sapiens HIV-1 Tat interactive protein, 60kDa (HTATIP).
LF344390 - JP 2014500723-A/151893: Polycomb-Associated Non-Coding RNAs.
LF344389 - JP 2014500723-A/151892: Polycomb-Associated Non-Coding RNAs.
JD043287 - Sequence 24311 from Patent EP1572962.
JD335145 - Sequence 316169 from Patent EP1572962.
JD410749 - Sequence 391773 from Patent EP1572962.
JD205313 - Sequence 186337 from Patent EP1572962.
JD067617 - Sequence 48641 from Patent EP1572962.
JD260081 - Sequence 241105 from Patent EP1572962.
JD342944 - Sequence 323968 from Patent EP1572962.
JD215022 - Sequence 196046 from Patent EP1572962.
JD205696 - Sequence 186720 from Patent EP1572962.
JD062716 - Sequence 43740 from Patent EP1572962.
JD359953 - Sequence 340977 from Patent EP1572962.
MA579970 - JP 2018138019-A/151896: Polycomb-Associated Non-Coding RNAs.
MA449633 - JP 2018138019-A/21559: Polycomb-Associated Non-Coding RNAs.
MA579969 - JP 2018138019-A/151895: Polycomb-Associated Non-Coding RNAs.
MA579967 - JP 2018138019-A/151893: Polycomb-Associated Non-Coding RNAs.
MA579966 - JP 2018138019-A/151892: Polycomb-Associated Non-Coding RNAs.
MA446749 - JP 2018138019-A/18675: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2

Reactome (by CSHL, EBI, and GO)

Protein Q92993 (Reactome details) participates in the following event(s):

R-HSA-3451153 Beta-catenin recruits TRRAP/KAT5 HAT components
R-HSA-5686410 BLM mediates dissolution of double Holliday junction
R-HSA-5686657 ERCC1:XPF cleaves flaps generated by SSA
R-HSA-5693589 D-loop dissociation and strand annealing
R-HSA-5693599 Association of Ku heterodimer with ends of DNA double-strand break
R-HSA-5682044 KAT5 acetylates ATM at DNA DSBs
R-HSA-5693612 MRN complex bound to DNA ends recruits ATM
R-HSA-5693540 MRN activates ATM
R-HSA-5682018 MRN complex bound to shortened telomeres recruits ATM
R-HSA-5693598 ATM phosphorylates NBN
R-HSA-5684081 MRN complex binds CDK2 and RBBP8
R-HSA-5693602 ATM recognizes H2AFX-Nucleosomes
R-HSA-5684071 RNF4 ubiquitinates MDC1
R-HSA-5685838 CX3 complex binds D-loop structures
R-HSA-5693620 D-loop formation mediated by PALB2, BRCA2 and RAD51
R-HSA-5682026 MRN bound to shortened telomeres activates ATM
R-HSA-6792712 KAT5 acetylates ATM at shortened telomeres
R-HSA-9023860 Histone acetyltransferases are recruited to the TFF1 gene
R-HSA-3321975 NuA4 complex acetylates histone H2A, HIST1H4
R-NUL-4551334 NuA4 complex actetylates H2A and H4
R-HSA-3451147 KAT5 HAT complex acetylates TCF4 gene at histone H4
R-HSA-5693583 MDC1 associates with gamma-H2AFX at nuclear foci
R-HSA-5683967 EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
R-HSA-5683986 APBB1 and MAPK8 bind diphosphorylated H2AFX
R-HSA-5693549 ATM phosphorylates histone H2AFX on S139 at DNA DSBs
R-HSA-5684096 CDK2 phosphorylates RBBP8
R-HSA-5684140 ATM phosphorylates RBBP8
R-HSA-5693608 Initial resection of double-strand break ends
R-HSA-5684108 BRCA1 binds phosphorylated RBBP8
R-HSA-5693542 Association of RPA complexes with ssDNA at resected DNA DSBs
R-HSA-5685994 Long-range resection of DNA DSBs by EXO1 or DNA2
R-HSA-5685341 BCDX2 complex stabilizes RAD51 filament
R-HSA-5693561 RAD51 binds BRCA2 at resected DNA DSBs
R-HSA-5693593 D-loop extension by DNA polymerases
R-HSA-5685985 EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
R-HSA-5693584 Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
R-HSA-5686440 MUS81:EME1,EME2 cleaves D-loop
R-HSA-5682967 WHSC1 binds DNA DSBs
R-HSA-5693536 ATM phosphorylates MDC1
R-HSA-5683964 ATM phosphorylates EYA1-4
R-HSA-5684875 Binding of ATR:ATRIP to RPA at resected DNA DSBs
R-HSA-5682983 ATM phosphorylates WHSC1
R-HSA-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs
R-HSA-5682992 KDM4A,B bind H4K20Me2
R-HSA-5685011 ATR activation at DNA DSBs
R-HSA-5684887 Activation of CHEK1 at resected DNA DSBs
R-HSA-5684882 CHEK1 is recruited to resected DNA DSBs
R-HSA-5693580 Association of RAD52 with the RPA complex at resected DNA DSBs
R-HSA-5685156 ATR phosphorylates RPA2
R-HSA-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs
R-HSA-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs
R-HSA-5683077 RNF8 and RNF168 ubiquitinate KDM4A,B
R-HSA-5693564 Association of RAD51 with RAD52:DNA double-strand break ends
R-HSA-5682586 HERC2 and PIAS4 are recruited to DNA DSBs
R-HSA-5682629 HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
R-HSA-5682607 PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
R-HSA-5682863 RNF168 binds DNA DSBs
R-HSA-5682858 RNF8 and RNF168 ubiquitinate H2AFX
R-HSA-5683384 UIMC1 and FAM175A bind DNA DSBs
R-HSA-5683405 PPP5C dephosphorylates TP53BP1
R-HSA-5683425 ATM phosphorylates TP53BP1 at DNA DSBs
R-HSA-6799332 ATR phosphorylates TP53
R-HSA-5686642 RAD52 promotes single strand annealing at resected DNA DSBs
R-HSA-5682598 ATM phosphorylates HERC2
R-HSA-5693551 Phosphorylation of BRCA1-A complex at multiple sites by ATM
R-HSA-5683385 Formation of BRCA1-A complex at DNA DSBs
R-HSA-5683735 CHEK2 is recruited to DNA DSBs
R-HSA-5683801 CHEK2 phosphorylates BRCA1
R-HSA-69891 Phosphorylation and activation of CHEK2 by ATM
R-HSA-5684052 PIAS4 SUMOylates MDC1
R-HSA-5686685 RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
R-HSA-5686900 TP53BP1 recruits DCLRE1C to ATM
R-HSA-5686704 Activated ATM phosphorylates DCLRE1C
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-5693548 Sensing of DNA Double Strand Breaks
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5693537 Resolution of D-Loop Structures
R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-3214847 HATs acetylate histones
R-HSA-2559583 Cellular Senescence
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-8939211 ESR-mediated signaling
R-HSA-195721 Signaling by WNT
R-HSA-5693538 Homology Directed Repair
R-HSA-73894 DNA Repair
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-2262752 Cellular responses to stress
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-162582 Signal Transduction
R-HSA-4839726 Chromatin organization
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69481 G2/M Checkpoints
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-1640170 Cell Cycle
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: HTATIP, NM_182710, NP_874369, Q92993-3, TIP60
UCSC ID: uc001ofk.3
RefSeq Accession: NM_182710
Protein: Q92993-3, splice isoform of Q92993 CCDS: CCDS8110.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182710.2
exon count: 13CDS single in 3' UTR: no RNA size: 2347
ORF size: 1641CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3139.00frame shift in genome: no % Coverage: 99.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 377# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.