Description: Homo sapiens heterogeneous nuclear ribonucleoprotein R (HNRNPR), transcript variant 1, mRNA. RefSeq Summary (NM_001102398): This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]. Transcript (Including UTRs) Position: hg19 chr1:23,636,276-23,670,853 Size: 34,578 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr1:23,636,947-23,667,501 Size: 30,555 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43390-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BX647784 - Homo sapiens mRNA; cDNA DKFZp686F0586 (from clone DKFZp686F0586). BX640912 - Homo sapiens mRNA; cDNA DKFZp686A13234 (from clone DKFZp686A13234). BC001449 - Homo sapiens heterogeneous nuclear ribonucleoprotein R, mRNA (cDNA clone MGC:2039 IMAGE:3139052), complete cds. LP895168 - Sequence 32 from Patent EP3253886. AK098580 - Homo sapiens cDNA FLJ25714 fis, clone TST05093, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein R mRNA. BX538163 - Homo sapiens mRNA; cDNA DKFZp686O0665 (from clone DKFZp686O0665); complete cds. AF000364 - Homo sapiens heterogeneous nuclear ribonucleoprotein R mRNA, complete cds. BC110389 - Homo sapiens heterogeneous nuclear ribonucleoprotein R, mRNA (cDNA clone IMAGE:5187023), partial cds. JD551120 - Sequence 532144 from Patent EP1572962. JD288705 - Sequence 269729 from Patent EP1572962. AK297382 - Homo sapiens cDNA FLJ53358 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein R. AK300029 - Homo sapiens cDNA FLJ54544 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein R. AK297405 - Homo sapiens cDNA FLJ53360 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein R. DQ351905 - Homo sapiens heterogeneous nuclear ribonucleoprotein-R2 mRNA, complete cds. DQ892168 - Synthetic construct clone IMAGE:100004798; FLH183638.01X; RZPDo839E11142D heterogeneous nuclear ribonucleoprotein R (HNRPR) gene, encodes complete protein. AK313142 - Homo sapiens cDNA, FLJ93632, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein R (HNRPR), mRNA. KJ892971 - Synthetic construct Homo sapiens clone ccsbBroadEn_02365 HNRNPR gene, encodes complete protein. DQ895362 - Synthetic construct Homo sapiens clone IMAGE:100009822; FLH183634.01L; RZPDo839E11141D heterogeneous nuclear ribonucleoprotein R (HNRPR) gene, encodes complete protein. AB385093 - Synthetic construct DNA, clone: pF1KB5396, Homo sapiens HNRNPR gene for heterogeneous nuclear ribonucleoprotein R, complete cds, without stop codon, in Flexi system. AK311519 - Homo sapiens cDNA, FLJ18561. CU674710 - Synthetic construct Homo sapiens gateway clone IMAGE:100017747 5' read HNRPR mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O43390 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing