Human Gene WASHC1 (uc010mgm.1)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: WASH1_HUMAN
DESCRIPTION: RecName: Full=WAS protein family homolog 1; AltName: Full=CXYorf1-like protein on chromosome 9; AltName: Full=Protein FAM39E;
FUNCTION: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. SUBUNIT: Component of the WASH complex, composed of F-actin- capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin- capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct. Interacts with alpha-tubulin. SUBCELLULAR LOCATION: Early endosome membrane. Recycling endosome membrane (By similarity). Note=Localization to the endodome membrane is mediated via its interaction with FAM21. MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene. SIMILARITY: Belongs to the WASH1 family. SIMILARITY: Contains 1 WH2 domain.
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Primer design for this transcript
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MalaCards Disease Associations
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR021854 - WASH_WASD
Pfam Domains: PF11945 - WAHD domain of WASH complex
ModBase Predicted Comparative 3D Structure on A8K0Z3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC094860 - Homo sapiens WAS protein family homolog 2 pseudogene, mRNA (cDNA clone IMAGE:4337266). BC064371 - Homo sapiens cDNA clone IMAGE:5588748, partial cds. BC073913 - Homo sapiens WAS protein family homolog 2 pseudogene, mRNA (cDNA clone IMAGE:5163655). BC093083 - Homo sapiens WAS protein family homolog 2 pseudogene, mRNA (cDNA clone IMAGE:30388014). BC063893 - Homo sapiens cDNA clone IMAGE:30368489, partial cds. BC014406 - Homo sapiens CXYorf1-related protein, mRNA (cDNA clone IMAGE:4639282), with apparent retained intron. BC027921 - Homo sapiens cDNA clone IMAGE:5225823, **** WARNING: chimeric clone ****. JD043865 - Sequence 24889 from Patent EP1572962. JD464022 - Sequence 445046 from Patent EP1572962. JD464023 - Sequence 445047 from Patent EP1572962. JD319762 - Sequence 300786 from Patent EP1572962. JD439184 - Sequence 420208 from Patent EP1572962. AK289708 - Homo sapiens cDNA FLJ75027 complete cds, highly similar to Homo sapiens CXYorf1-related protein (MGC52000), mRNA. JD386972 - Sequence 367996 from Patent EP1572962. JD469492 - Sequence 450516 from Patent EP1572962. BC160141 - Synthetic construct Homo sapiens clone IMAGE:100064173, MGC:193256 WASH1 protein (WASH1) mRNA, encodes complete protein. BC156859 - Synthetic construct Homo sapiens clone IMAGE:100062519, MGC:190539 WAS protein family homolog 1 (WASH1) mRNA, encodes complete protein. JD371043 - Sequence 352067 from Patent EP1572962. JD178321 - Sequence 159345 from Patent EP1572962. JD371044 - Sequence 352068 from Patent EP1572962. JD044295 - Sequence 25319 from Patent EP1572962. JD433165 - Sequence 414189 from Patent EP1572962. JD460507 - Sequence 441531 from Patent EP1572962. AK296182 - Homo sapiens cDNA FLJ50976 complete cds. JD406735 - Sequence 387759 from Patent EP1572962. JD455749 - Sequence 436773 from Patent EP1572962. JD115443 - Sequence 96467 from Patent EP1572962. JD365642 - Sequence 346666 from Patent EP1572962. JD123346 - Sequence 104370 from Patent EP1572962. JD054019 - Sequence 35043 from Patent EP1572962. JD309150 - Sequence 290174 from Patent EP1572962. JD114876 - Sequence 95900 from Patent EP1572962. JD270338 - Sequence 251362 from Patent EP1572962. JD392218 - Sequence 373242 from Patent EP1572962. AK309568 - Homo sapiens cDNA, FLJ99609. JD520988 - Sequence 502012 from Patent EP1572962. JD164536 - Sequence 145560 from Patent EP1572962. JD145347 - Sequence 126371 from Patent EP1572962. JD493632 - Sequence 474656 from Patent EP1572962. JD295896 - Sequence 276920 from Patent EP1572962. JD273037 - Sequence 254061 from Patent EP1572962. JD267962 - Sequence 248986 from Patent EP1572962. JD090362 - Sequence 71386 from Patent EP1572962. JD090361 - Sequence 71385 from Patent EP1572962. JD338175 - Sequence 319199 from Patent EP1572962. JD544421 - Sequence 525445 from Patent EP1572962. AK308540 - Homo sapiens cDNA, FLJ98581. JD283908 - Sequence 264932 from Patent EP1572962. JD405726 - Sequence 386750 from Patent EP1572962. JD405727 - Sequence 386751 from Patent EP1572962. JD127621 - Sequence 108645 from Patent EP1572962. JD408497 - Sequence 389521 from Patent EP1572962. JD100811 - Sequence 81835 from Patent EP1572962. JD461476 - Sequence 442500 from Patent EP1572962. JD170368 - Sequence 151392 from Patent EP1572962. JD519949 - Sequence 500973 from Patent EP1572962. JD042751 - Sequence 23775 from Patent EP1572962. JD098685 - Sequence 79709 from Patent EP1572962. JD151500 - Sequence 132524 from Patent EP1572962. JD540282 - Sequence 521306 from Patent EP1572962. JD442700 - Sequence 423724 from Patent EP1572962. JD370682 - Sequence 351706 from Patent EP1572962. AK308635 - Homo sapiens cDNA, FLJ98676. AK024448 - Homo sapiens mRNA for FLJ00038 protein, partial cds. JD488237 - Sequence 469261 from Patent EP1572962. JD193028 - Sequence 174052 from Patent EP1572962. JD172831 - Sequence 153855 from Patent EP1572962. JD565176 - Sequence 546200 from Patent EP1572962.
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Other Names for This Gene
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Alternate Gene Symbols: A8K0Z3, FAM39E, NM_182905, NP_878908, WASH1, WASH1_HUMAN UCSC ID: uc010mgm.1 RefSeq Accession: NM_182905
Protein: A8K0Z3
(aka WASH1_HUMAN)
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Gene Model Information
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category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_182905.4
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exon count:
| 11 | CDS single in 3' UTR:
| no
| RNA size:
| 1837 |
ORF size:
| 1398 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 2993.00 | frame shift in genome:
| no
| % Coverage:
| 100.00 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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