Human Gene ABHD17C (uc002bfu.3)
  Description: Homo sapiens abhydrolase domain containing 17C (ABHD17C), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:80,987,652-81,047,962 Size: 60,311 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr15:80,987,771-81,046,711 Size: 58,941 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:80,987,652-81,047,962)mRNA (may differ from genome)Protein (329 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F108C_HUMAN
DESCRIPTION: RecName: Full=Abhydrolase domain-containing protein FAM108C1; EC=3.-.-.-;
SIMILARITY: Belongs to the AB hydrolase superfamily. FAM108 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.40 RPKM in Colon - Transverse
Total median expression: 242.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.80119-0.393 Picture PostScript Text
3' UTR -309.601251-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00326 - Prolyl oligopeptidase family
PF12146 - Serine aminopeptidase, S33

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q6PCB6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0002084 protein depalmitoylation
GO:0018345 protein palmitoylation
GO:1902817 negative regulation of protein localization to microtubule
GO:1905668 positive regulation of protein localization to endosome

Cellular Component:
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0042995 cell projection
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0055038 recycling endosome membrane


-  Descriptions from all associated GenBank mRNAs
  BC115003 - Homo sapiens family with sequence similarity 108, member C1, mRNA (cDNA clone MGC:131546 IMAGE:7503983), complete cds.
BC059401 - Homo sapiens family with sequence similarity 108, member C1, mRNA (cDNA clone MGC:71761 IMAGE:30346383), complete cds.
AL390079 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 588495.
AK298606 - Homo sapiens cDNA FLJ57493 complete cds.
AK092758 - Homo sapiens cDNA FLJ35439 fis, clone SMINT2002899.
JD399243 - Sequence 380267 from Patent EP1572962.
JD396549 - Sequence 377573 from Patent EP1572962.
JC593203 - Sequence 8694 from Patent EP2736539.
JC595381 - Sequence 10872 from Patent EP2736539.
JC588839 - Sequence 4330 from Patent EP2736539.
JC591019 - Sequence 6510 from Patent EP2736539.
JC593199 - Sequence 8690 from Patent EP2736539.
JC591020 - Sequence 6511 from Patent EP2736539.
JC593200 - Sequence 8691 from Patent EP2736539.
JC595378 - Sequence 10869 from Patent EP2736539.
JC593201 - Sequence 8692 from Patent EP2736539.
JC595379 - Sequence 10870 from Patent EP2736539.
JC595380 - Sequence 10871 from Patent EP2736539.
JC588840 - Sequence 4331 from Patent EP2736539.
JC591021 - Sequence 6512 from Patent EP2736539.
JC593202 - Sequence 8693 from Patent EP2736539.
JC588841 - Sequence 4332 from Patent EP2736539.
JC591022 - Sequence 6513 from Patent EP2736539.
JD395675 - Sequence 376699 from Patent EP1572962.
JD381538 - Sequence 362562 from Patent EP1572962.
AK091780 - Homo sapiens cDNA FLJ34461 fis, clone HLUNG2002949.
AX747179 - Sequence 704 from Patent EP1308459.
JD043717 - Sequence 24741 from Patent EP1572962.
JD171984 - Sequence 153008 from Patent EP1572962.
JD509105 - Sequence 490129 from Patent EP1572962.
JD428659 - Sequence 409683 from Patent EP1572962.
JD137392 - Sequence 118416 from Patent EP1572962.
JD500764 - Sequence 481788 from Patent EP1572962.
JD258921 - Sequence 239945 from Patent EP1572962.
JD168114 - Sequence 149138 from Patent EP1572962.
JD049451 - Sequence 30475 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: F108C_HUMAN, FAM108C1, NM_021214, NP_067037, Q1RMD6, Q6PCB6, Q9NPM1
UCSC ID: uc002bfu.3
RefSeq Accession: NM_021214
Protein: Q6PCB6 (aka F108C_HUMAN)
CCDS: CCDS45323.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_021214.1
exon count: 3CDS single in 3' UTR: no RNA size: 2408
ORF size: 990CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1936.50frame shift in genome: no % Coverage: 98.01
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.