Description: Homo sapiens kallikrein-related peptidase 10 (KLK10), transcript variant 3, mRNA. RefSeq Summary (NM_001077500): Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:51,516,000-51,523,431 Size: 7,432 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr19:51,518,056-51,522,386 Size: 4,331 Coding Exon Count: 5
ID:KLK10_HUMAN DESCRIPTION: RecName: Full=Kallikrein-10; EC=3.4.21.-; AltName: Full=Normal epithelial cell-specific 1; AltName: Full=Protease serine-like 1; Flags: Precursor; FUNCTION: Has a tumor-suppressor role for NES1 in breast and prostate cancer. SUBCELLULAR LOCATION: Secreted (Probable). TISSUE SPECIFICITY: Expressed in breast, ovary and prostate. DEVELOPMENTAL STAGE: Down-regulated during breast cancer progression. SIMILARITY: Belongs to the peptidase S1 family. Kallikrein subfamily. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/KLK10ID41076ch19q13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43240
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
