Human Gene PSKH2 (uc011lfy.2)
  Description: Homo sapiens protein serine kinase H2 (PSKH2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:87,060,691-87,081,851 Size: 21,161 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr8:87,060,691-87,081,851 Size: 21,161 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:87,060,691-87,081,851)mRNA (may differ from genome)Protein (385 aa)
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HGNCHPRDLynxMGIneXtProtPubMed
TreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KPSH2_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase H2; EC=2.7.11.1; AltName: Full=Protein serine kinase H2; Short=PSK-H2;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.
CAUTION: Asn-183 is present instead of the conserved Asp which is expected to be an active site residue.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PSKH2
CDC HuGE Published Literature: PSKH2

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.08 RPKM in Testis
Total median expression: 0.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020636 - Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
47473 - EF-hand
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q96QS6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BC126180 - Homo sapiens protein serine kinase H2, mRNA (cDNA clone MGC:161458 IMAGE:8991896), complete cds.
BC144195 - Homo sapiens cDNA clone IMAGE:9052715, containing frame-shift errors.
BC126182 - Homo sapiens protein serine kinase H2, mRNA (cDNA clone MGC:161460 IMAGE:8991898), complete cds.
AY037806 - Homo sapiens serine/threonine kinase PSKH2 (PSKH2) mRNA, complete cds.
HQ258398 - Synthetic construct Homo sapiens clone IMAGE:100072827 protein serine kinase H2 (PSKH2) gene, encodes complete protein.
KJ899874 - Synthetic construct Homo sapiens clone ccsbBroadEn_09268 PSKH2 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A0AV22, KPSH2_HUMAN, NM_033126, NP_149117, Q96QS6
UCSC ID: uc011lfy.2
RefSeq Accession: NM_033126
Protein: Q96QS6 (aka KPSH2_HUMAN)
CCDS: CCDS6240.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033126.1
exon count: 3CDS single in 3' UTR: no RNA size: 1158
ORF size: 1158CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2516.00frame shift in genome: no % Coverage: 99.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.