Description: Homo sapiens integrator complex subunit 12 (INTS12), transcript variant 2, mRNA. RefSeq Summary (NM_001142471): INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr4:106,603,785-106,629,881 Size: 26,097 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr4:106,603,890-106,621,162 Size: 17,273 Coding Exon Count: 6
ID:INT12_HUMAN DESCRIPTION: RecName: Full=Integrator complex subunit 12; Short=Int12; AltName: Full=PHD finger protein 22; FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. SUBUNIT: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Contains 1 PHD-type zinc finger. SEQUENCE CAUTION: Sequence=AAF99604.1; Type=Frameshift; Positions=439;
pulmonary function Hancock ,et al. 2009, Meta-analyses of genome-wide assocation studies identify multiple loci associated with pulmonary function, Nature genetics 2010 42- 1 : 45-52.
[PubMed 20010835]
Respiratory Function Tests Dana B Hancock et al. Nature genetics 2010, Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function., Nature genetics.
[PubMed 20010835]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96CB8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
