Description: Homo sapiens serine/threonine/tyrosine kinase 1 (STYK1), mRNA. RefSeq Summary (NM_018423): Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr12:10,771,538-10,826,891 Size: 55,354 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr12:10,772,743-10,787,217 Size: 14,475 Coding Exon Count: 9
ID:STYK1_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein kinase STYK1; EC=2.7.10.2; AltName: Full=Novel oncogene with kinase domain; AltName: Full=Protein PK-unique; AltName: Full=Serine/threonine/tyrosine kinase 1; FUNCTION: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SIMILARITY: Contains 1 protein kinase domain.
Echocardiography Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903301]
In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q6J9G0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Cellular Component: GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Descriptions from all associated GenBank mRNAs
AL353940 - Homo sapiens mRNA; cDNA DKFZp761P1010 (from clone DKFZp761P1010). JD080657 - Sequence 61681 from Patent EP1572962. JD509156 - Sequence 490180 from Patent EP1572962. AF251059 - Homo sapiens kinase domain protein mRNA, complete cds. JD095950 - Sequence 76974 from Patent EP1572962. JD130947 - Sequence 111971 from Patent EP1572962. JD192208 - Sequence 173232 from Patent EP1572962. JD237140 - Sequence 218164 from Patent EP1572962. JD061029 - Sequence 42053 from Patent EP1572962. JD207330 - Sequence 188354 from Patent EP1572962. JD314989 - Sequence 296013 from Patent EP1572962. JD258895 - Sequence 239919 from Patent EP1572962. BC093822 - Homo sapiens serine/threonine/tyrosine kinase 1, mRNA (cDNA clone MGC:120857 IMAGE:7939667), complete cds. BC093824 - Homo sapiens serine/threonine/tyrosine kinase 1, mRNA (cDNA clone MGC:120859 IMAGE:7939669), complete cds. AY563054 - Homo sapiens tyrosine kinase protein mRNA, complete cds. KP729000 - Homo sapiens NOK mRNA, complete cds. AK313906 - Homo sapiens cDNA, FLJ94543. AB463252 - Synthetic construct DNA, clone: pF1KB8676, Homo sapiens STYK1 gene for serine/threonine/tyrosine kinase 1, without stop codon, in Flexi system. AM393808 - Synthetic construct Homo sapiens clone IMAGE:100001903 for hypothetical protein (STYK1 gene). JD358407 - Sequence 339431 from Patent EP1572962. JD463469 - Sequence 444493 from Patent EP1572962. JD350845 - Sequence 331869 from Patent EP1572962.
US Server
