Human Gene NOC2L (uc031pkq.1) Description and Page Index
  Description: Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae) (NOC2L), mRNA.
RefSeq Summary (NM_015658): Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225239.1, AK024284.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327044.7/ ENSP00000317992.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr1:879,583-882,440 Size: 2,858 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:880,074-881,970 Size: 1,897 Coding Exon Count: 5 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:879,583-882,440)mRNA (may differ from genome)Protein (216 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS

-  MalaCards Disease Associations
  MalaCards Gene Search: NOC2L
Diseases sorted by gene-association score: corneal dystrophy, posterior amorphous (2), retinitis pigmentosa, y-linked (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.24 RPKM in Testis
Total median expression: 1231.11 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -202.60470-0.431 Picture PostScript Text
3' UTR -216.30491-0.441 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005343 - UPF0120

Pfam Domains:
PF03715 - Noc2p family

ModBase Predicted Comparative 3D Structure on Q8NAK7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AF161376 - Homo sapiens HSPC258 mRNA, partial cds.
AK225239 - Homo sapiens mRNA for Nucleolar complex protein 2 homolog, clone: COL07101.
AK092491 - Homo sapiens cDNA FLJ35172 fis, clone PLACE6013232.
AX747569 - Sequence 1094 from Patent EP1308459.
AK022756 - Homo sapiens cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186).
AK024284 - Homo sapiens cDNA FLJ14222 fis, clone NT2RP3003992, highly similar to Nucleolar complex protein 2 homolog.
AL050019 - Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186).
BC003555 - Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae), mRNA (cDNA clone MGC:1451 IMAGE:3546209), complete cds.
JD451658 - Sequence 432682 from Patent EP1572962.
JD493513 - Sequence 474537 from Patent EP1572962.
JD393947 - Sequence 374971 from Patent EP1572962.
JD252686 - Sequence 233710 from Patent EP1572962.
JD079681 - Sequence 60705 from Patent EP1572962.
JD198987 - Sequence 180011 from Patent EP1572962.
JD223744 - Sequence 204768 from Patent EP1572962.
JD454297 - Sequence 435321 from Patent EP1572962.
JD353504 - Sequence 334528 from Patent EP1572962.
AK315080 - Homo sapiens cDNA, FLJ96036.
KJ898602 - Synthetic construct Homo sapiens clone ccsbBroadEn_07996 NOC2L gene, encodes complete protein.
AB463150 - Synthetic construct DNA, clone: pF1KB8582, Homo sapiens NOC2L gene for nucleolar complex associated 2 homolog, without stop codon, in Flexi system.
AM393843 - Synthetic construct Homo sapiens clone IMAGE:100001909 for hypothetical protein (NOC2L gene).

-  Other Names for This Gene
  Alternate Gene Symbols: AX747569, Q8NAK7, Q8NAK7_HUMAN, uc001aby.4
UCSC ID: uc031pkq.1
RefSeq Accession: NM_015658
Protein: Q8NAK7

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AX747569.1
exon count: 5CDS single in 3' UTR: no RNA size: 1611
ORF size: 651CDS single in intron: no Alignment % ID: 99.75
txCdsPredict score: 883.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 515# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.