Human Gene SLC22A31 (uc021tmr.1) Description and Page Index
  Description: Homo sapiens solute carrier family 22, member 31 (SLC22A31), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:89,262,169-89,266,529 Size: 4,361 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr16:89,262,407-89,265,558 Size: 3,152 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:89,262,169-89,266,529)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
MGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative solute carrier family 22 member 31;
FUNCTION: Organic anion transporter that mediates the uptake of ions (Potential).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 133.80 RPKM in Brain - Cerebellum
Total median expression: 312.25 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -300.04605-0.496 Picture PostScript Text
3' UTR -115.80238-0.487 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR005828 - Sub_transporter

Pfam Domains:
PF00083 - Sugar (and other) transporter

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on A6NKX4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008514 organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0015711 organic anion transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AL137382 - Homo sapiens mRNA; cDNA DKFZp434L1226 (from clone DKFZp434L1226).
JD054123 - Sequence 35147 from Patent EP1572962.
JD475766 - Sequence 456790 from Patent EP1572962.
JD455289 - Sequence 436313 from Patent EP1572962.
JD277163 - Sequence 258187 from Patent EP1572962.
JD135499 - Sequence 116523 from Patent EP1572962.
JD541516 - Sequence 522540 from Patent EP1572962.
JD161442 - Sequence 142466 from Patent EP1572962.
JD174826 - Sequence 155850 from Patent EP1572962.
JD121176 - Sequence 102200 from Patent EP1572962.
JD545675 - Sequence 526699 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NKX4, NM_001242757, NP_001229686, S22AV_HUMAN
UCSC ID: uc021tmr.1
RefSeq Accession: NM_001242757
Protein: A6NKX4 (aka S22AV_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001242757.1
exon count: 8CDS single in 3' UTR: no RNA size: 1860
ORF size: 1017CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2120.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.