Human Gene AP1G1 (uc021tky.1) Description and Page Index
  Description: Homo sapiens adaptor-related protein complex 1, gamma 1 subunit (AP1G1), transcript variant 2, mRNA.
RefSeq Summary (NM_001030007): Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr16:71,762,905-71,823,385 Size: 60,481 Total Exon Count: 23 Strand: -
Coding Region
   Position: hg19 chr16:71,766,961-71,823,382 Size: 56,422 Coding Exon Count: 23 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:71,762,905-71,823,385)mRNA (may differ from genome)Protein (825 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): AP1G1
CDC HuGE Published Literature: AP1G1

-  MalaCards Disease Associations
  MalaCards Gene Search: AP1G1
Diseases sorted by gene-association score: hypoactive sexual desire disorder (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.13 RPKM in Testis
Total median expression: 533.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -1190.844056-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF01602 - Adaptin N terminal region
PF02883 - Adaptin C-terminal domain
PF12717 - non-SMC mitotic condensation complex subunit 1

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain
49348 - Clathrin adaptor appendage domain

ModBase Predicted Comparative 3D Structure on O43747-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC036283 - Homo sapiens adaptor-related protein complex 1, gamma 1 subunit, mRNA (cDNA clone MGC:18255 IMAGE:4158263), complete cds.
AK128078 - Homo sapiens cDNA FLJ46199 fis, clone TESTI4007965, highly similar to AP-1 complex subunit gamma-1.
Y12226 - H.sapiens mRNA for gamma-adaptin.
AK293233 - Homo sapiens cDNA FLJ55047 complete cds, highly similar to AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma-1 subunit) (Gamma-adaptin)(Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).
AB015317 - Homo sapiens mRNA for gamma1-adaptin, complete cds.
AK225906 - Homo sapiens mRNA for adaptor-related protein complex 1, gamma 1 subunit isoform a variant, clone: FCC119H01.
AK314484 - Homo sapiens cDNA, FLJ95292.
AK299630 - Homo sapiens cDNA FLJ55587 complete cds, highly similar to AP-1 complex subunit gamma-1 (Adapter-relatedprotein complex 1 gamma- 1 subunit) (Gamma-adaptin)(Adaptor protein complex AP-1 gamma-1 subunit) (Golgiadaptor HA1/AP1 adaptin subunit gamma-1) (Clathrinassembly protein complex 1 gamma-1 large chain).
AK294546 - Homo sapiens cDNA FLJ52990 complete cds, highly similar to AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma-1 subunit) (Gamma-adaptin)(Adaptor protein complex AP-1 gamma-1 subunit) (Golgiadaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).
AK025020 - Homo sapiens cDNA: FLJ21367 fis, clone COL03051.
BC003414 - Homo sapiens adaptor-related protein complex 1, gamma 1 subunit, mRNA (cDNA clone IMAGE:3451138), partial cds.
BC051747 - Homo sapiens adaptor-related protein complex 1, gamma 1 subunit, mRNA (cDNA clone IMAGE:5263221).
JD023460 - Sequence 4484 from Patent EP1572962.
JD029278 - Sequence 10302 from Patent EP1572962.
JD029563 - Sequence 10587 from Patent EP1572962.
AL110198 - Homo sapiens mRNA; cDNA DKFZp586B1622 (from clone DKFZp586B1622).
AK055122 - Homo sapiens cDNA FLJ30560 fis, clone BRAWH2004217, highly similar to AP-1 complex subunit gamma-1.
JD532463 - Sequence 513487 from Patent EP1572962.
JD240790 - Sequence 221814 from Patent EP1572962.
JD560275 - Sequence 541299 from Patent EP1572962.
JD043818 - Sequence 24842 from Patent EP1572962.
JD358977 - Sequence 340001 from Patent EP1572962.
JD206400 - Sequence 187424 from Patent EP1572962.
JD060351 - Sequence 41375 from Patent EP1572962.
JD291232 - Sequence 272256 from Patent EP1572962.
JD554750 - Sequence 535774 from Patent EP1572962.
JD242078 - Sequence 223102 from Patent EP1572962.
JD327792 - Sequence 308816 from Patent EP1572962.
JD061385 - Sequence 42409 from Patent EP1572962.
JD115334 - Sequence 96358 from Patent EP1572962.
JD185796 - Sequence 166820 from Patent EP1572962.
JD367344 - Sequence 348368 from Patent EP1572962.
JD185548 - Sequence 166572 from Patent EP1572962.
JD327638 - Sequence 308662 from Patent EP1572962.
JD533406 - Sequence 514430 from Patent EP1572962.
JD120812 - Sequence 101836 from Patent EP1572962.
HM005334 - Homo sapiens clone HTL-T-21 testicular tissue protein Li 21 mRNA, complete cds.
JD327535 - Sequence 308559 from Patent EP1572962.
EU832486 - Synthetic construct Homo sapiens clone HAIB:100067515; DKFZo008E0329 adaptor-related protein complex 1, gamma 1 subunit protein (AP1G1) gene, encodes complete protein.
EU832566 - Synthetic construct Homo sapiens clone HAIB:100067595; DKFZo004E0330 adaptor-related protein complex 1, gamma 1 subunit protein (AP1G1) gene, encodes complete protein.
AB527830 - Synthetic construct DNA, clone: pF1KB5777, Homo sapiens AP1G1 gene for adaptor-related protein complex 1, gamma 1 subunit, without stop codon, in Flexi system.
AL050025 - Homo sapiens mRNA; cDNA DKFZp564D066 (from clone DKFZp564D066).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04142 - Lysosome

Reactome (by CSHL, EBI, and GO)

Protein O43747 (Reactome details) participates in the following event(s):

R-HSA-182279 Formation of MHC I:Nef:AP-1:PACS-1 Complex
R-HSA-421833 Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture
R-HSA-432712 Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane
R-HSA-421836 trans-Golgi Network Derived Vesicle Uncoating
R-HSA-432688 trans-Golgi Network Derived Lysosomal Vesicle Uncoating
R-HSA-2213236 TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome
R-HSA-182286 Transport of MHC I:Nef:AP-1:PACS-1 Complex
R-HSA-8951498 Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex
R-HSA-421831 trans-Golgi Network Coat Assembly
R-HSA-432706 trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly
R-HSA-421835 trans-Golgi Network Vesicle Scission
R-HSA-432707 trans-Golgi Network Lysosomal Vesicle Scission
R-HSA-2130641 Translocation of TGN-lysosome vesicle to lysosome
R-HSA-5333658 CLAT:AP1:CLVS bind PI(3,5)P2
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-2132295 MHC class II antigen presentation
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
R-HSA-421837 Clathrin derived vesicle budding
R-HSA-1280218 Adaptive Immune System
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-168256 Immune System
R-HSA-162909 Host Interactions of HIV factors
R-HSA-199991 Membrane Trafficking
R-HSA-162906 HIV Infection
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: ADTG, CCDS45522, CLAPG1, NM_001030007, NP_001025178, O43747-2
UCSC ID: uc021tky.1
RefSeq Accession: NM_001030007
Protein: O43747-2, splice isoform of O43747 CCDS: CCDS32480.1, CCDS45522.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: CCDS45522.1
exon count: 23CDS single in 3' UTR: no RNA size: 6537
ORF size: 2478CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4935.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.