Human Gene FGFBP3 (uc021pwg.1) Description and Page Index
  Description: Homo sapiens fibroblast growth factor binding protein 3 (FGFBP3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:93,667,950-93,668,726 Size: 777 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr10:93,667,950-93,668,726 Size: 777 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:93,667,950-93,668,726)mRNA (may differ from genome)Protein (258 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaCGAP
Entrez GeneExonPrimerGeneCardsHGNCHPRDLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FGFP3_HUMAN
DESCRIPTION: RecName: Full=Fibroblast growth factor-binding protein 3; Short=FGF-BP3; Short=FGF-binding protein 3; Short=FGFBP-3; Flags: Precursor;
SUBUNIT: Interacts with FGF1.
SUBCELLULAR LOCATION: Secreted (Probable).
SIMILARITY: Belongs to the fibroblast growth factor-binding protein family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D014212 Tretinoin
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • D001564 Benzo(a)pyrene
  • D019327 Copper Sulfate
  • D004041 Dietary Fats
  • D011794 Quercetin
  • D014635 Valproic Acid
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010510 - FGF1-bd

Pfam Domains:
PF06473 - FGF binding protein 1 (FGF-BP1)

ModBase Predicted Comparative 3D Structure on Q8TAT2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
GO:0019838 growth factor binding

Biological Process:
GO:0043117 positive regulation of vascular permeability
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0031012 extracellular matrix


-  Descriptions from all associated GenBank mRNAs
  AK075410 - Homo sapiens cDNA PSEC0101 fis, clone NT2RP2003115.
LF211308 - JP 2014500723-A/18811: Polycomb-Associated Non-Coding RNAs.
BC025966 - Homo sapiens fibroblast growth factor binding protein 3, mRNA (cDNA clone MGC:39320 IMAGE:4895171), complete cds.
DQ503576 - Homo sapiens fibroblast growth factor binding protein 3 mRNA, complete cds.
AK315427 - Homo sapiens cDNA, FLJ96482.
AB464522 - Synthetic construct DNA, clone: pF1KB8778, Homo sapiens FGFBP3 gene for fibroblast growth factor binding protein 3, without stop codon, in Flexi system.
JD202739 - Sequence 183763 from Patent EP1572962.
MA446885 - JP 2018138019-A/18811: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TAT2 (Reactome details) participates in the following event(s):

R-HSA-5656070 FGFBPs bind FGFs
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-5654738 Signaling by FGFR2
R-HSA-190236 Signaling by FGFR
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD68, C10orf13, CCDS7418, FGFP3_HUMAN, NM_152429, NP_689642, PSEC0101, Q8NBN0, Q8TAT2
UCSC ID: uc021pwg.1
Representative RNA: CCDS7418 Protein: Q8TAT2 (aka FGFP3_HUMAN)
CCDS: CCDS7418.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: CCDS7418.1
exon count: 1CDS single in 3' UTR: no RNA size: 777
ORF size: 777CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1639.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.