Human Gene FGFBP3 (uc021pwg.1) Description and Page Index
  Description: Homo sapiens fibroblast growth factor binding protein 3 (FGFBP3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:93,667,950-93,668,726 Size: 777 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr10:93,667,950-93,668,726 Size: 777 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:93,667,950-93,668,726)mRNA (may differ from genome)Protein (258 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaCGAP
Entrez GeneExonPrimerGeneCardsHGNCHPRDLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Fibroblast growth factor-binding protein 3; Short=FGF-BP3; Short=FGF-binding protein 3; Short=FGFBP-3; Flags: Precursor;
SUBUNIT: Interacts with FGF1.
SUBCELLULAR LOCATION: Secreted (Probable).
SIMILARITY: Belongs to the fibroblast growth factor-binding protein family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D014212 Tretinoin
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • D001564 Benzo(a)pyrene
  • D019327 Copper Sulfate
  • D004041 Dietary Fats
  • D011794 Quercetin
  • D014635 Valproic Acid
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010510 - FGF1-bd

Pfam Domains:
PF06473 - FGF binding protein 1 (FGF-BP1)

ModBase Predicted Comparative 3D Structure on Q8TAT2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
GO:0019838 growth factor binding

Biological Process:
GO:0043117 positive regulation of vascular permeability
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0031012 extracellular matrix

-  Descriptions from all associated GenBank mRNAs
  AK075410 - Homo sapiens cDNA PSEC0101 fis, clone NT2RP2003115.
LF211308 - JP 2014500723-A/18811: Polycomb-Associated Non-Coding RNAs.
BC025966 - Homo sapiens fibroblast growth factor binding protein 3, mRNA (cDNA clone MGC:39320 IMAGE:4895171), complete cds.
DQ503576 - Homo sapiens fibroblast growth factor binding protein 3 mRNA, complete cds.
AK315427 - Homo sapiens cDNA, FLJ96482.
AB464522 - Synthetic construct DNA, clone: pF1KB8778, Homo sapiens FGFBP3 gene for fibroblast growth factor binding protein 3, without stop codon, in Flexi system.
JD202739 - Sequence 183763 from Patent EP1572962.
MA446885 - JP 2018138019-A/18811: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TAT2 (Reactome details) participates in the following event(s):

R-HSA-5656070 FGFBPs bind FGFs
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-5654738 Signaling by FGFR2
R-HSA-190236 Signaling by FGFR
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD68, C10orf13, CCDS7418, FGFP3_HUMAN, NM_152429, NP_689642, PSEC0101, Q8NBN0, Q8TAT2
UCSC ID: uc021pwg.1
Representative RNA: CCDS7418 Protein: Q8TAT2 (aka FGFP3_HUMAN)
CCDS: CCDS7418.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: CCDS7418.1
exon count: 1CDS single in 3' UTR: no RNA size: 777
ORF size: 777CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1639.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.