Human Gene ATF3 (uc021pit.1) Description and Page Index
Description: Homo sapiens activating transcription factor 3 (ATF3), transcript variant 5, mRNA. RefSeq Summary (NM_001206484): This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]. Transcript (Including UTRs) Position: hg19 chr1:212,781,970-212,794,119 Size: 12,150 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr1:212,788,535-212,792,897 Size: 4,363 Coding Exon Count: 3
ID:ATF3_HUMAN DESCRIPTION: RecName: Full=Cyclic AMP-dependent transcription factor ATF-3; Short=cAMP-dependent transcription factor ATF-3; AltName: Full=Activating transcription factor 3; FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. SUBUNIT: Binds DNA as a homodimer or a heterodimer. INTERACTION: Self; NbExp=2; IntAct=EBI-712767, EBI-712767; Q14192:FHL2; NbExp=3; IntAct=EBI-712767, EBI-701903; Q04206:RELA; NbExp=4; IntAct=EBI-712767, EBI-73886; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the bZIP family. ATF subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/atf3/";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ATF3 CDC HuGE Published Literature: ATF3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18847
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0044212 transcription regulatory region DNA binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006094 gluconeogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0008284 positive regulation of cell proliferation GO:0010628 positive regulation of gene expression GO:0030968 endoplasmic reticulum unfolded protein response GO:0034198 cellular response to amino acid starvation GO:0035914 skeletal muscle cell differentiation GO:0036499 PERK-mediated unfolded protein response GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress