Human Gene GAS8 (uc010vpt.1) Description and Page Index
  Description: Homo sapiens growth arrest-specific 8 (GAS8), transcript variant 1, mRNA.
RefSeq Summary (NM_001481): This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].
Transcript (Including UTRs)
   Position: hg19 chr16:90,089,008-90,103,807 Size: 14,800 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr16:90,089,130-90,102,818 Size: 13,689 Coding Exon Count: 5 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:90,089,008-90,103,807)mRNA (may differ from genome)Protein (174 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMGIPubMedStanford SOURCEUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GAS8
CDC HuGE Published Literature: GAS8
Positive Disease Associations: Heart Failure
Related Studies:
  1. Heart Failure
    , , . [PubMed 0]
  2. Heart Failure
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: GAS8
Diseases sorted by gene-association score: ciliary dyskinesia, primary, 33* (919), primary ciliary dyskinesia 33: gas8-related primary ciliary dyskinesia* (500), primary ciliary dyskinesia (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.44 RPKM in Pituitary
Total median expression: 359.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.70122-0.539 Picture PostScript Text
3' UTR -370.63989-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on B7Z9B0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK297857 - Homo sapiens cDNA FLJ56118 complete cds, highly similar to Growth-arrest-specific protein 8.
AF050079 - Homo sapiens growth arrest specific 11 (GAS11) mRNA, complete cds.
GQ891399 - Homo sapiens clone HEL-S-110 epididymis secretory sperm binding protein mRNA, complete cds.
BC104785 - Homo sapiens growth arrest-specific 8, mRNA (cDNA clone MGC:132445 IMAGE:8143788), complete cds.
BC112121 - Homo sapiens growth arrest-specific 8, mRNA (cDNA clone MGC:138326 IMAGE:8327589), complete cds.
AK303505 - Homo sapiens cDNA FLJ59808 complete cds, highly similar to Growth-arrest-specific protein 8.
AK315261 - Homo sapiens cDNA, FLJ96270, Homo sapiens growth arrest-specific 8 (GAS8), mRNA.
AK294050 - Homo sapiens cDNA FLJ51714 complete cds, highly similar to Growth-arrest-specific protein 8.
AK304731 - Homo sapiens cDNA FLJ55405 complete cds, highly similar to Growth-arrest-specific protein 8.
BX647947 - Homo sapiens mRNA; cDNA DKFZp686C0751 (from clone DKFZp686C0751).
AK293958 - Homo sapiens cDNA FLJ52408 complete cds, highly similar to Growth-arrest-specific protein 8.
KJ896862 - Synthetic construct Homo sapiens clone ccsbBroadEn_06256 GAS8-like gene, encodes complete protein.
CR749499 - Homo sapiens mRNA; cDNA DKFZp686C09209 (from clone DKFZp686C09209).

-  Other Names for This Gene
  Alternate Gene Symbols: AK304731, B7Z9B0, B7Z9B0_HUMAN
UCSC ID: uc010vpt.1
RefSeq Accession: NM_001481
Protein: B7Z9B0

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK304731.1
exon count: 5CDS single in 3' UTR: no RNA size: 1080
ORF size: 525CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 1250.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.