Human Gene AP1G1 (uc010vmg.1) Description and Page Index
  Description: Homo sapiens adaptor-related protein complex 1, gamma 1 subunit (AP1G1), transcript variant 2, mRNA.
RefSeq Summary (NM_001128): Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr16:71,792,711-71,842,976 Size: 50,266 Total Exon Count: 12 Strand: -


Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:71,792,711-71,842,976)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneNetworkH-INVHGNC
LynxPubMedStanford SOURCEWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): AP1G1
CDC HuGE Published Literature: AP1G1

-  MalaCards Disease Associations
  MalaCards Gene Search: AP1G1
Diseases sorted by gene-association score: hypoactive sexual desire disorder (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.13 RPKM in Testis
Total median expression: 533.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC036283 - Homo sapiens adaptor-related protein complex 1, gamma 1 subunit, mRNA (cDNA clone MGC:18255 IMAGE:4158263), complete cds.
AK128078 - Homo sapiens cDNA FLJ46199 fis, clone TESTI4007965, highly similar to AP-1 complex subunit gamma-1.
Y12226 - H.sapiens mRNA for gamma-adaptin.
AK293233 - Homo sapiens cDNA FLJ55047 complete cds, highly similar to AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma-1 subunit) (Gamma-adaptin)(Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).
AB015317 - Homo sapiens mRNA for gamma1-adaptin, complete cds.
AK225906 - Homo sapiens mRNA for adaptor-related protein complex 1, gamma 1 subunit isoform a variant, clone: FCC119H01.
AK314484 - Homo sapiens cDNA, FLJ95292.
AK299630 - Homo sapiens cDNA FLJ55587 complete cds, highly similar to AP-1 complex subunit gamma-1 (Adapter-relatedprotein complex 1 gamma- 1 subunit) (Gamma-adaptin)(Adaptor protein complex AP-1 gamma-1 subunit) (Golgiadaptor HA1/AP1 adaptin subunit gamma-1) (Clathrinassembly protein complex 1 gamma-1 large chain).
AK294546 - Homo sapiens cDNA FLJ52990 complete cds, highly similar to AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 gamma-1 subunit) (Gamma-adaptin)(Adaptor protein complex AP-1 gamma-1 subunit) (Golgiadaptor HA1/AP1 adaptin subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain).
HM005334 - Homo sapiens clone HTL-T-21 testicular tissue protein Li 21 mRNA, complete cds.
EU832486 - Synthetic construct Homo sapiens clone HAIB:100067515; DKFZo008E0329 adaptor-related protein complex 1, gamma 1 subunit protein (AP1G1) gene, encodes complete protein.
EU832566 - Synthetic construct Homo sapiens clone HAIB:100067595; DKFZo004E0330 adaptor-related protein complex 1, gamma 1 subunit protein (AP1G1) gene, encodes complete protein.
AB527830 - Synthetic construct DNA, clone: pF1KB5777, Homo sapiens AP1G1 gene for adaptor-related protein complex 1, gamma 1 subunit, without stop codon, in Flexi system.
AL050025 - Homo sapiens mRNA; cDNA DKFZp564D066 (from clone DKFZp564D066).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04142 - Lysosome

-  Other Names for This Gene
  Alternate Gene Symbols: AK294546
UCSC ID: uc010vmg.1
RefSeq Accession: NM_001128

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AK294546.1
exon count: 12CDS single in 3' UTR: no RNA size: 1166
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 700.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.