Human Gene TATDN3 (uc010ptm.1) Description and Page Index
  Description: Homo sapiens TatD DNase domain containing 3 (TATDN3), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:212,968,352-212,990,167 Size: 21,816 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr1:212,969,916-212,988,498 Size: 18,583 Coding Exon Count: 8 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:212,968,352-212,990,167)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TATDN3
CDC HuGE Published Literature: TATDN3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.14 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 192.71 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.76175-0.261 Picture PostScript Text
3' UTR -453.571669-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001130 - TatD_family

Pfam Domains:
PF01026 - TatD related DNase

SCOP Domains:
51556 - Metallo-dependent hydrolases

ModBase Predicted Comparative 3D Structure on B7Z2Z9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016788 hydrolase activity, acting on ester bonds

-  Descriptions from all associated GenBank mRNAs
  AK293129 - Homo sapiens cDNA FLJ52692 complete cds.
AK304557 - Homo sapiens cDNA FLJ54907 complete cds.
BC113638 - Homo sapiens TatD DNase domain containing 3, mRNA (cDNA clone MGC:142198 IMAGE:8322690), complete cds.
BC117485 - Homo sapiens TatD DNase domain containing 3, mRNA (cDNA clone MGC:151094 IMAGE:40126036), complete cds.
BC143956 - Homo sapiens TatD DNase domain containing 3, mRNA (cDNA clone MGC:177491 IMAGE:9052474), complete cds.
BC143957 - Homo sapiens cDNA clone IMAGE:9052475.
AL832248 - Homo sapiens mRNA; cDNA DKFZp686O2377 (from clone DKFZp686O2377).
BC048115 - Homo sapiens TatD DNase domain containing 3, mRNA (cDNA clone IMAGE:5259047), partial cds.
HQ258161 - Synthetic construct Homo sapiens clone IMAGE:100072470 TatD DNase domain containing 3 (TATDN3) gene, encodes complete protein.
AK295335 - Homo sapiens cDNA FLJ53789 complete cds.
JD400351 - Sequence 381375 from Patent EP1572962.
JD349844 - Sequence 330868 from Patent EP1572962.
JD130110 - Sequence 111134 from Patent EP1572962.
JD327070 - Sequence 308094 from Patent EP1572962.
JD300697 - Sequence 281721 from Patent EP1572962.
JD292083 - Sequence 273107 from Patent EP1572962.
JD485434 - Sequence 466458 from Patent EP1572962.
JD482338 - Sequence 463362 from Patent EP1572962.
JD181570 - Sequence 162594 from Patent EP1572962.
JD139412 - Sequence 120436 from Patent EP1572962.
JD448873 - Sequence 429897 from Patent EP1572962.
JD087058 - Sequence 68082 from Patent EP1572962.
JD262060 - Sequence 243084 from Patent EP1572962.
JD262179 - Sequence 243203 from Patent EP1572962.
JD165326 - Sequence 146350 from Patent EP1572962.
JD560934 - Sequence 541958 from Patent EP1572962.
JD561047 - Sequence 542071 from Patent EP1572962.
JD542892 - Sequence 523916 from Patent EP1572962.
JD212996 - Sequence 194020 from Patent EP1572962.
JD059593 - Sequence 40617 from Patent EP1572962.
JD533816 - Sequence 514840 from Patent EP1572962.
JD095260 - Sequence 76284 from Patent EP1572962.
JD489619 - Sequence 470643 from Patent EP1572962.
JD505389 - Sequence 486413 from Patent EP1572962.
JD106925 - Sequence 87949 from Patent EP1572962.
JD377506 - Sequence 358530 from Patent EP1572962.
JD280820 - Sequence 261844 from Patent EP1572962.
JD173266 - Sequence 154290 from Patent EP1572962.
JD515169 - Sequence 496193 from Patent EP1572962.
JD107336 - Sequence 88360 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK295335, B7Z2Z9, B7Z2Z9_HUMAN, NM_001042553, NP_001036018
UCSC ID: uc010ptm.1
RefSeq Accession: NM_001042553
Protein: B7Z2Z9

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK295335.1
exon count: 9CDS single in 3' UTR: no RNA size: 860
ORF size: 666CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1335.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 85# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.