Human Gene PPP2R5A (uc010ptd.2) Description and Page Index
  Description: Homo sapiens protein phosphatase 2, regulatory subunit B', alpha (PPP2R5A), transcript variant 2, mRNA.
RefSeq Summary (NM_001199756): The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: hg19 chr1:212,475,148-212,535,205 Size: 60,058 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr1:212,475,425-212,534,112 Size: 58,688 Coding Exon Count: 13 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:212,475,148-212,535,205)mRNA (may differ from genome)Protein (429 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
ReactomeStanford SOURCETreefamUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: PPP2R5A
Diseases sorted by gene-association score: cardiomyopathy, dilated, 1d (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.23 RPKM in Adipose - Subcutaneous
Total median expression: 894.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.60277-0.201 Picture PostScript Text
3' UTR -293.701093-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF01603 - Protein phosphatase 2A regulatory B subunit (B56 family)

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q15172-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK312530 - Homo sapiens cDNA, FLJ92899, Homo sapiens protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A), mRNA.
L42373 - Homo sapiens phosphatase 2A B56-alpha (PP2A) mRNA, complete cds.
BC110883 - Homo sapiens protein phosphatase 2, regulatory subunit B', alpha isoform, mRNA (cDNA clone MGC:131915 IMAGE:6045358), complete cds.
BC022474 - Homo sapiens protein phosphatase 2, regulatory subunit B', alpha isoform, mRNA (cDNA clone MGC:26270 IMAGE:4815091), complete cds.
AB527512 - Synthetic construct DNA, clone: pF1KB5848, Homo sapiens PPP2R5A gene for protein phosphatase 2, regulatory subunit B', alpha isoform, without stop codon, in Flexi system.
DQ895568 - Synthetic construct Homo sapiens clone IMAGE:100010028; FLH185545.01L; RZPDo839C05147D protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) gene, encodes complete protein.
DQ892361 - Synthetic construct clone IMAGE:100004991; FLH185549.01X; RZPDo839C05148D protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) gene, encodes complete protein.
AK302202 - Homo sapiens cDNA FLJ51383 complete cds, highly similar to Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform.
JD510206 - Sequence 491230 from Patent EP1572962.
JD285931 - Sequence 266955 from Patent EP1572962.
JD519300 - Sequence 500324 from Patent EP1572962.
JD545378 - Sequence 526402 from Patent EP1572962.
JD293794 - Sequence 274818 from Patent EP1572962.
JD412590 - Sequence 393614 from Patent EP1572962.
JD363569 - Sequence 344593 from Patent EP1572962.
JD453353 - Sequence 434377 from Patent EP1572962.
JD146459 - Sequence 127483 from Patent EP1572962.
JD519439 - Sequence 500463 from Patent EP1572962.
JD150723 - Sequence 131747 from Patent EP1572962.
JD504876 - Sequence 485900 from Patent EP1572962.
JD537185 - Sequence 518209 from Patent EP1572962.
JD059875 - Sequence 40899 from Patent EP1572962.
JD200951 - Sequence 181975 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04114 - Oocyte meiosis
hsa04310 - Wnt signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q15172 (Reactome details) participates in the following event(s):

R-HSA-195251 Assembly of the destruction complex
R-HSA-389532 PP2A binds CTLA4 homodimer
R-HSA-432143 PECAM-1 binds PP2A
R-HSA-8857925 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
R-HSA-201685 Beta-catenin is released from the destruction complex
R-HSA-388833 Phosphorylation of CTLA-4
R-HSA-5229343 AXIN is phosphorylated in the destruction complex
R-HSA-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
R-HSA-195275 Phosphorylation of APC component of the destruction complex
R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
R-HSA-141409 Mad1 binds kinetochore
R-HSA-375302 Kinetochore capture of astral microtubules
R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores
R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
R-HSA-388809 CTLA-4 binds B7-1/B7-2
R-HSA-195304 Association of beta-catenin with the destruction complex
R-HSA-390329 Dephosphorylation of AKT by PP2A
R-HSA-5672957 PP2A dephosphorylates KSR1
R-HSA-5672961 PP2A dephosphorylates inactive RAFs
R-HSA-5675431 PP2A dephosphorylates RAF1
R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex
R-HSA-141439 Release of activated MAD2 from kinetochores
R-HSA-2467811 Separation of sister chromatids
R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin
R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores
R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha
R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1
R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin
R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres
R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-432142 Platelet sensitization by LDL
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-68877 Mitotic Prometaphase
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-195721 Signaling by WNT
R-HSA-388841 Costimulation by the CD28 family
R-HSA-418346 Platelet homeostasis
R-HSA-4839744 truncated APC mutants destabilize the destruction complex
R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-4839748 AMER1 mutants destabilize the destruction complex
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5673000 RAF activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-141424 Amplification of signal from the kinetochores
R-HSA-68886 M Phase
R-HSA-195258 RHO GTPase Effectors
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-162582 Signal Transduction
R-HSA-1280218 Adaptive Immune System
R-HSA-109582 Hemostasis
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-68882 Mitotic Anaphase
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-194315 Signaling by Rho GTPases
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-5683057 MAPK family signaling cascades

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001199756, NP_001186685, Q15172-2
UCSC ID: uc010ptd.2
RefSeq Accession: NM_001199756
Protein: Q15172-2, splice isoform of Q15172 CCDS: CCDS55686.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001199756.1
exon count: 13CDS single in 3' UTR: no RNA size: 2667
ORF size: 1290CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2572.50frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.