Human Gene GPR89B (uc010ozt.2) Description and Page Index
Description: Homo sapiens G protein-coupled receptor 89B (GPR89B), mRNA.
RefSeq Summary (NM_001097613): GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009].
Transcript (Including UTRs)
Position: hg19 chr1:147,400,506-147,465,755 Size: 65,250 Total Exon Count: 15 Strand: +
Position: hg19 chr1:147,408,774-147,465,149 Size: 56,376 Coding Exon Count: 13
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Golgi pH regulator A; AltName: Full=Protein GPR89A; AltName: Full=Putative MAPK-activating protein PM01; AltName: Full=Putative NF-kappa-B-activating protein 90;
FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity). SUBUNIT: Homotrimer (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Ubiquitous. MISCELLANEOUS: Does not seem to be able to bind GTP. SIMILARITY: Belongs to the Golgi pH regulator (TC 1.A.38) family.
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR025969 - ABA_GPCR_dom
IPR022535 - Golgi_pH-regulator_cons_dom
IPR015672 - GPCR89-rel
Pfam Domains: PF12430 - Abscisic acid G-protein coupled receptor
PF12537 - The Golgi pH Regulator (GPHR) Family N-terminal
ModBase Predicted Comparative 3D Structure on B7ZAQ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK021758 - Homo sapiens cDNA FLJ11696 fis, clone HEMBA1005029, highly similar to Protein GPR89A. AL133020 - Homo sapiens mRNA; cDNA DKFZp434H1228 (from clone DKFZp434H1228). AY358966 - Homo sapiens clone DNA30867 SH120 (UNQ192) mRNA, complete cds. AK299995 - Homo sapiens cDNA FLJ61382 complete cds, highly similar to Protein GPR89A. AK302266 - Homo sapiens cDNA FLJ55546 complete cds, highly similar to Protein GPR89A. AK223223 - Homo sapiens mRNA for G protein-coupled receptor 89 variant, clone: STM00985. AB097024 - Homo sapiens mRNA for putative NFkB activating protein, complete cds, clone: 90. AB097025 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM01. BC067816 - Homo sapiens G protein-coupled receptor 89A, mRNA (cDNA clone MGC:87324 IMAGE:5295014), complete cds. U78723 - Human putative G-protein coupled receptor (SH120) mRNA, complete cds. AF132947 - Homo sapiens CGI-13 protein mRNA, complete cds. BC146880 - Homo sapiens G protein-coupled receptor 89B, mRNA (cDNA clone MGC:181983 IMAGE:9056808), complete cds. AK316371 - Homo sapiens cDNA, FLJ79270 complete cds, highly similar to Protein GPR89A. BC003187 - Homo sapiens G protein-coupled receptor 89A, mRNA (cDNA clone MGC:688 IMAGE:3537949), complete cds. AB528816 - Synthetic construct DNA, clone: pF1KE0287, Homo sapiens GPR89B gene for G protein-coupled receptor 89B, without stop codon, in Flexi system. BC156843 - Synthetic construct Homo sapiens clone IMAGE:100062517, MGC:190537 G protein-coupled receptor 89B (GPR89B) mRNA, encodes complete protein. DQ890650 - Synthetic construct clone IMAGE:100003280; FLH164783.01X; RZPDo839B11158D G protein-coupled receptor 89A (GPR89A) gene, encodes complete protein. DQ893830 - Synthetic construct Homo sapiens clone IMAGE:100008290; FLH164779.01L; RZPDo839B11157D G protein-coupled receptor 89A (GPR89A) gene, encodes complete protein. KJ534847 - Homo sapiens clone GPR89A_iso-C_adult-A09 G protein-coupled receptor 89A isoform C (GPR89A) mRNA, partial cds, alternatively spliced. KJ534848 - Homo sapiens clone GPR89A_iso-B_adult-A13 G protein-coupled receptor 89A isoform B (GPR89A) mRNA, partial cds, alternatively spliced. KJ534849 - Homo sapiens clone GPR89B_iso-B_adult-A02 G protein-coupled receptor 89B isoform B (GPR89B) mRNA, partial cds, alternatively spliced. KJ534850 - Homo sapiens clone GPR89B_iso-C_adult-A06 G protein-coupled receptor 89B isoform C (GPR89B) mRNA, partial cds, alternatively spliced. KJ534851 - Homo sapiens clone GPR89B_iso-D_fetal-F05 G protein-coupled receptor 89B isoform D (GPR89B) mRNA, partial cds, alternatively spliced. KJ535029 - Homo sapiens clone GPR89A_iso-D_adult-A16 G protein-coupled receptor 89A isoform D (GPR89A) mRNA, complete cds, alternatively spliced. KJ535049 - Homo sapiens clone GPR89A_iso-A_adult-A11 G protein-coupled receptor 89A isoform A (GPR89A) mRNA, complete cds, alternatively spliced. KJ535070 - Homo sapiens clone GPR89B_iso-A_fetal-F07 G protein-coupled receptor 89B isoform A (GPR89B) mRNA, complete cds, alternatively spliced. BT006679 - Homo sapiens putative G-protein coupled receptor mRNA, complete cds. KJ905123 - Synthetic construct Homo sapiens clone ccsbBroadEn_14517 GPR89A-like gene, encodes complete protein. AK301939 - Homo sapiens cDNA FLJ52656 complete cds, highly similar to Protein GPR89A. CU688354 - Synthetic construct Homo sapiens gateway clone IMAGE:100023218 5' read GPR89A mRNA. LP895152 - Sequence 16 from Patent EP3253886. AF151035 - Homo sapiens HSPC201 mRNA, complete cds. JD214175 - Sequence 195199 from Patent EP1572962. JD044718 - Sequence 25742 from Patent EP1572962. JD225141 - Sequence 206165 from Patent EP1572962. JD323430 - Sequence 304454 from Patent EP1572962. JD377575 - Sequence 358599 from Patent EP1572962. JD111077 - Sequence 92101 from Patent EP1572962. JD064920 - Sequence 45944 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A6NN37, AK316371, B2RUV3, B3KMN3, B4DXE7, B7ZAQ6, CGI-13, GPHRA, GPHRA_HUMAN, GPR89, GPR89A, NM_001097613, NP_001091082, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302, SH120, UNQ192/PRO218 UCSC ID: uc010ozt.2 RefSeq Accession: NM_001097613
(aka GPHRA_HUMAN) B7ZAQ6
Gene Model Information
15 CDS single in 3' UTR:
1293 CDS single in intron:
Alignment % ID:
2412.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.