Human Gene GPR89B (uc010ozt.2) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 89B (GPR89B), mRNA.
RefSeq Summary (NM_001097613): GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009].
Transcript (Including UTRs)
   Position: hg19 chr1:147,400,506-147,465,755 Size: 65,250 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr1:147,408,774-147,465,149 Size: 56,376 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:147,400,506-147,465,755)mRNA (may differ from genome)Protein (430 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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H-INVHGNCLynxMGIneXtProtOMIM
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-  Comments and Description Text from UniProtKB
  ID: GPHRA_HUMAN
DESCRIPTION: RecName: Full=Golgi pH regulator A; AltName: Full=Protein GPR89A; AltName: Full=Putative MAPK-activating protein PM01; AltName: Full=Putative NF-kappa-B-activating protein 90;
FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity).
SUBUNIT: Homotrimer (By similarity).
SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
MISCELLANEOUS: Does not seem to be able to bind GTP.
SIMILARITY: Belongs to the Golgi pH regulator (TC 1.A.38) family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.56 RPKM in Testis
Total median expression: 14.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.20265-0.393 Picture PostScript Text
3' UTR -175.44606-0.290 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025969 - ABA_GPCR_dom
IPR022535 - Golgi_pH-regulator_cons_dom
IPR015672 - GPCR89-rel

Pfam Domains:
PF12430 - Abscisic acid G-protein coupled receptor
PF12537 - The Golgi pH Regulator (GPHR) Family N-terminal

ModBase Predicted Comparative 3D Structure on B7ZAQ6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005244 voltage-gated ion channel activity
GO:0008308 voltage-gated anion channel activity

Biological Process:
GO:0006811 ion transport
GO:0015031 protein transport
GO:0015698 inorganic anion transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051452 intracellular pH reduction

Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0032580 Golgi cisterna membrane


-  Descriptions from all associated GenBank mRNAs
  AK021758 - Homo sapiens cDNA FLJ11696 fis, clone HEMBA1005029, highly similar to Protein GPR89A.
AL133020 - Homo sapiens mRNA; cDNA DKFZp434H1228 (from clone DKFZp434H1228).
AY358966 - Homo sapiens clone DNA30867 SH120 (UNQ192) mRNA, complete cds.
AK299995 - Homo sapiens cDNA FLJ61382 complete cds, highly similar to Protein GPR89A.
AK302266 - Homo sapiens cDNA FLJ55546 complete cds, highly similar to Protein GPR89A.
AK223223 - Homo sapiens mRNA for G protein-coupled receptor 89 variant, clone: STM00985.
AB097024 - Homo sapiens mRNA for putative NFkB activating protein, complete cds, clone: 90.
AB097025 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM01.
BC067816 - Homo sapiens G protein-coupled receptor 89A, mRNA (cDNA clone MGC:87324 IMAGE:5295014), complete cds.
U78723 - Human putative G-protein coupled receptor (SH120) mRNA, complete cds.
AF132947 - Homo sapiens CGI-13 protein mRNA, complete cds.
BC146880 - Homo sapiens G protein-coupled receptor 89B, mRNA (cDNA clone MGC:181983 IMAGE:9056808), complete cds.
AK316371 - Homo sapiens cDNA, FLJ79270 complete cds, highly similar to Protein GPR89A.
BC003187 - Homo sapiens G protein-coupled receptor 89A, mRNA (cDNA clone MGC:688 IMAGE:3537949), complete cds.
AB528816 - Synthetic construct DNA, clone: pF1KE0287, Homo sapiens GPR89B gene for G protein-coupled receptor 89B, without stop codon, in Flexi system.
BC156843 - Synthetic construct Homo sapiens clone IMAGE:100062517, MGC:190537 G protein-coupled receptor 89B (GPR89B) mRNA, encodes complete protein.
DQ890650 - Synthetic construct clone IMAGE:100003280; FLH164783.01X; RZPDo839B11158D G protein-coupled receptor 89A (GPR89A) gene, encodes complete protein.
DQ893830 - Synthetic construct Homo sapiens clone IMAGE:100008290; FLH164779.01L; RZPDo839B11157D G protein-coupled receptor 89A (GPR89A) gene, encodes complete protein.
KJ534847 - Homo sapiens clone GPR89A_iso-C_adult-A09 G protein-coupled receptor 89A isoform C (GPR89A) mRNA, partial cds, alternatively spliced.
KJ534848 - Homo sapiens clone GPR89A_iso-B_adult-A13 G protein-coupled receptor 89A isoform B (GPR89A) mRNA, partial cds, alternatively spliced.
KJ534849 - Homo sapiens clone GPR89B_iso-B_adult-A02 G protein-coupled receptor 89B isoform B (GPR89B) mRNA, partial cds, alternatively spliced.
KJ534850 - Homo sapiens clone GPR89B_iso-C_adult-A06 G protein-coupled receptor 89B isoform C (GPR89B) mRNA, partial cds, alternatively spliced.
KJ534851 - Homo sapiens clone GPR89B_iso-D_fetal-F05 G protein-coupled receptor 89B isoform D (GPR89B) mRNA, partial cds, alternatively spliced.
KJ535029 - Homo sapiens clone GPR89A_iso-D_adult-A16 G protein-coupled receptor 89A isoform D (GPR89A) mRNA, complete cds, alternatively spliced.
KJ535049 - Homo sapiens clone GPR89A_iso-A_adult-A11 G protein-coupled receptor 89A isoform A (GPR89A) mRNA, complete cds, alternatively spliced.
KJ535070 - Homo sapiens clone GPR89B_iso-A_fetal-F07 G protein-coupled receptor 89B isoform A (GPR89B) mRNA, complete cds, alternatively spliced.
BT006679 - Homo sapiens putative G-protein coupled receptor mRNA, complete cds.
KJ905123 - Synthetic construct Homo sapiens clone ccsbBroadEn_14517 GPR89A-like gene, encodes complete protein.
AK301939 - Homo sapiens cDNA FLJ52656 complete cds, highly similar to Protein GPR89A.
CU688354 - Synthetic construct Homo sapiens gateway clone IMAGE:100023218 5' read GPR89A mRNA.
LP895152 - Sequence 16 from Patent EP3253886.
AF151035 - Homo sapiens HSPC201 mRNA, complete cds.
JD214175 - Sequence 195199 from Patent EP1572962.
JD044718 - Sequence 25742 from Patent EP1572962.
JD225141 - Sequence 206165 from Patent EP1572962.
JD323430 - Sequence 304454 from Patent EP1572962.
JD377575 - Sequence 358599 from Patent EP1572962.
JD111077 - Sequence 92101 from Patent EP1572962.
JD064920 - Sequence 45944 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NN37, AK316371, B2RUV3, B3KMN3, B4DXE7, B7ZAQ6, CGI-13, GPHRA, GPHRA_HUMAN, GPR89, GPR89A, NM_001097613, NP_001091082, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302, SH120, UNQ192/PRO218
UCSC ID: uc010ozt.2
RefSeq Accession: NM_001097613
Protein: B7ZAQ6 (aka GPHRA_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK316371.1
exon count: 15CDS single in 3' UTR: no RNA size: 1644
ORF size: 1293CDS single in intron: no Alignment % ID: 99.82
txCdsPredict score: 2412.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.