Human Gene CD226 (uc010dqo.3) Description and Page Index
Description: Homo sapiens CD226 molecule (CD226), mRNA.
RefSeq Summary (NM_006566): This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Transcript (Including UTRs)
Position: hg19 chr18:67,530,193-67,615,089 Size: 84,897 Total Exon Count: 6 Strand: -
Position: hg19 chr18:67,531,550-67,614,642 Size: 83,093 Coding Exon Count: 6
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=CD226 antigen; AltName: Full=DNAX accessory molecule 1; Short=DNAM-1; AltName: CD_antigen=CD226; Flags: Precursor;
FUNCTION: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. SUBUNIT: Interacts with PVR and PVRL2. INTERACTION: Q92692:PVRL2; NbExp=2; IntAct=EBI-4314442, EBI-718419; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Expressed by peripheral blood T-lymphocytes. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
CD226 CDC HuGE Published Literature:
CD226 Positive Disease Associations: Diabetes Mellitus, Type 1
, mean platelet volume
, type 1 diabetes
Diabetes Mellitus, Type 1 John A Todd et al. Nature genetics 2007, Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes., Nature genetics.
Diabetes Mellitus, Type 1 Vincent Plagnol et al. PLoS genetics 2011, Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases., PLoS genetics.
mean platelet volume Soranzo ,et al. 2009, A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium, Nature genetics 2009 41- 11 : 1182-90.
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MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set
Pfam Domains: PF07686 - Immunoglobulin V-set domain
SCOP Domains: 48726 - Immunoglobulin
ModBase Predicted Comparative 3D Structure on Q15762
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005178 integrin binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process: GO:0001816 cytokine production
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007165 signal transduction
GO:0008037 cell recognition
GO:0032729 positive regulation of interferon-gamma production
GO:0033005 positive regulation of mast cell activation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
Cellular Component: GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005913 cell-cell adherens junction
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Descriptions from all associated GenBank mRNAs
GU935335 - Homo sapiens CD226 antigen Delta 12 nt mutant (CD226) mRNA, complete sequence, alternatively spliced. GU935336 - Homo sapiens CD226 antigen Delta exon 2-3 (CD226) mRNA, complete sequence, alternatively spliced. U56102 - Human adhesion molecule DNAM-1 mRNA, complete cds. JD172534 - Sequence 153558 from Patent EP1572962. JD208260 - Sequence 189284 from Patent EP1572962. JD224237 - Sequence 205261 from Patent EP1572962. JD440941 - Sequence 421965 from Patent EP1572962. JD353256 - Sequence 334280 from Patent EP1572962. JD493294 - Sequence 474318 from Patent EP1572962. JD304667 - Sequence 285691 from Patent EP1572962. JD501876 - Sequence 482900 from Patent EP1572962. JD181541 - Sequence 162565 from Patent EP1572962. JD206161 - Sequence 187185 from Patent EP1572962. JD077171 - Sequence 58195 from Patent EP1572962. JD077810 - Sequence 58834 from Patent EP1572962. JD444371 - Sequence 425395 from Patent EP1572962. JD453181 - Sequence 434205 from Patent EP1572962. JD131566 - Sequence 112590 from Patent EP1572962. JD355967 - Sequence 336991 from Patent EP1572962. JD507687 - Sequence 488711 from Patent EP1572962. AJ537553 - Homo sapiens mRNA for DNAM-1 protein. BC074787 - Homo sapiens CD226 molecule, mRNA (cDNA clone MGC:104109 IMAGE:30915562), complete cds. AK313199 - Homo sapiens cDNA, FLJ93698, highly similar to Homo sapiens CD226 antigen (CD226), mRNA. KJ898272 - Synthetic construct Homo sapiens clone ccsbBroadEn_07666 CD226 gene, encodes complete protein.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: AK313199, B2R818, CD226_HUMAN, DNAM1, NM_006566, NP_006557, Q15762 UCSC ID: uc010dqo.3 RefSeq Accession: NM_006566
(aka CD226_HUMAN or C226_HUMAN) Q15762
Gene Model Information
6 CDS single in 3' UTR:
1011 CDS single in intron:
Alignment % ID:
2024.50 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
420 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.