Human Gene PRDM7 (uc010cje.3) Description and Page Index
Description: Homo sapiens PR domain containing 7 (PRDM7), transcript variant 1, mRNA. RefSeq Summary (NM_001098173): This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013]. ##Evidence-Data-START## Transcript exon combination :: AM690991.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr16:90,122,974-90,142,338 Size: 19,365 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr16:90,124,697-90,142,318 Size: 17,622 Coding Exon Count: 10
ID:PRDM7_HUMAN DESCRIPTION: RecName: Full=Probable histone-lysine N-methyltransferase PRDM7; EC=184.108.40.206; AltName: Full=PR domain zinc finger protein 7; AltName: Full=PR domain-containing protein 7; FUNCTION: Probable histone methyltransferase (By similarity). CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBCELLULAR LOCATION: Nucleus (Potential). Chromosome (Potential). MISCELLANEOUS: The mouse orthologous protein seems not to exist. According to PubMed:17916234, human PRDM7 and PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, were generated by a recent gene duplication event after the divergence of the ancestors of human and mouse. SIMILARITY: Contains 1 KRAB-related domain. SIMILARITY: Contains 1 SET domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PRDM7 CDC HuGE Published Literature: PRDM7 Positive Disease Associations: Heart Failure Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQW5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.