Human Gene ZNF276 (uc010cis.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 276 (ZNF276), transcript variant b, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:89,787,393-89,807,332 Size: 19,940 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr16:89,789,835-89,804,654 Size: 14,820 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:89,787,393-89,807,332)mRNA (may differ from genome)Protein (373 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 276; Short=Zfp-276; AltName: Full=Zinc finger protein 477;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SIMILARITY: Contains 1 ZAD (zinc-finger associated) domain.
SEQUENCE CAUTION: Sequence=AAH32781.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI10349.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.32 RPKM in Brain - Cerebellum
Total median expression: 563.47 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -437.22886-0.493 Picture PostScript Text
3' UTR -1082.602678-0.404 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012934 - Znf_AD
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q8N554
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005694 chromosome

-  Descriptions from all associated GenBank mRNAs
  AK289801 - Homo sapiens cDNA FLJ77809 complete cds.
AK056405 - Homo sapiens cDNA FLJ31843 fis, clone NT2RP7000271, highly similar to Zinc finger protein 276.
BC105959 - Homo sapiens zinc finger protein 276, mRNA (cDNA clone MGC:126480 IMAGE:40036181), complete cds.
BC107603 - Homo sapiens zinc finger protein 276, mRNA (cDNA clone MGC:126479 IMAGE:40036180), complete cds.
BC111408 - Homo sapiens zinc finger protein 276, mRNA (cDNA clone IMAGE:40036175), with apparent retained intron.
AK026482 - Homo sapiens cDNA: FLJ22829 fis, clone KAIA4075, highly similar to HSCH16FAA Homo sapiens mRNA for FAA protein.
BC110348 - Homo sapiens zinc finger protein 276, mRNA (cDNA clone MGC:111410 IMAGE:5196957), complete cds.
AF354755 - Homo sapiens zinc finger protein 276 (ZFP276) mRNA, complete cds.
AF354756 - Homo sapiens zinc finger protein 276 (ZFP276) mRNA, complete cds.
EU446558 - Synthetic construct Homo sapiens clone IMAGE:100070182; IMAGE:100011767; FLH257322.01L zinc finger protein 276 (ZNF276) gene, encodes complete protein.
EU831852 - Synthetic construct Homo sapiens clone HAIB:100066881; DKFZo004C0622 zinc finger protein 276 protein (ZNF276) gene, encodes complete protein.
EU831774 - Synthetic construct Homo sapiens clone HAIB:100066803; DKFZo008C0621 zinc finger protein 276 protein (ZNF276) gene, encodes complete protein.
KJ899957 - Synthetic construct Homo sapiens clone ccsbBroadEn_09351 ZNF276 gene, encodes complete protein.
BC032781 - Homo sapiens zinc finger protein 276, mRNA (cDNA clone IMAGE:4944210), partial cds.
JD163375 - Sequence 144399 from Patent EP1572962.
JD566182 - Sequence 547206 from Patent EP1572962.
JD116515 - Sequence 97539 from Patent EP1572962.
JD269378 - Sequence 250402 from Patent EP1572962.
JD189162 - Sequence 170186 from Patent EP1572962.
JD115033 - Sequence 96057 from Patent EP1572962.
AK295770 - Homo sapiens cDNA FLJ59696 complete cds, highly similar to Zinc finger protein 276.
JD380038 - Sequence 361062 from Patent EP1572962.
AK315793 - Homo sapiens cDNA, FLJ96912.
JD182577 - Sequence 163601 from Patent EP1572962.
JD189589 - Sequence 170613 from Patent EP1572962.
JD137843 - Sequence 118867 from Patent EP1572962.
CU689532 - Synthetic construct Homo sapiens gateway clone IMAGE:100019128 5' read ZNF276 mRNA.
KJ903588 - Synthetic construct Homo sapiens clone ccsbBroadEn_12982 ZNF276 gene, encodes complete protein.
AK096762 - Homo sapiens cDNA FLJ39443 fis, clone PROST2006688, highly similar to Mus musculus zinc finger protein 276 C2H2 type (Zfp276) mRNA.
BC038839 - Homo sapiens zinc finger protein 276, mRNA (cDNA clone IMAGE:5175132).
JD075590 - Sequence 56614 from Patent EP1572962.
JD041160 - Sequence 22184 from Patent EP1572962.
JD116356 - Sequence 97380 from Patent EP1572962.
JD322885 - Sequence 303909 from Patent EP1572962.
JD452047 - Sequence 433071 from Patent EP1572962.
JD534549 - Sequence 515573 from Patent EP1572962.
AK096004 - Homo sapiens cDNA FLJ38685 fis, clone KIDNE2000909.
JD024682 - Sequence 5706 from Patent EP1572962.
JD028788 - Sequence 9812 from Patent EP1572962.
DQ586843 - Homo sapiens piRNA piR-53955, complete sequence.
DQ594670 - Homo sapiens piRNA piR-60782, complete sequence.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_bard1Pathway - BRCA1-dependent Ub-ligase activity
h_atrbrcaPathway - Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility

-  Other Names for This Gene
  Alternate Gene Symbols: BC111408, Q0VGA1, Q2TBE8, Q3B7H7, Q8N554, ZFP276, ZN276_HUMAN, ZNF477
UCSC ID: uc010cis.3
RefSeq Accession: NM_152287
Protein: Q8N554 (aka ZN276_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC111408.1
exon count: 10CDS single in 3' UTR: no RNA size: 3403
ORF size: 1122CDS single in intron: no Alignment % ID: 99.88
txCdsPredict score: 1858.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.