Human Gene CDH15 (uc010cij.1) Description and Page Index
  Description: Homo sapiens cadherin 15, type 1, M-cadherin (myotubule) (CDH15), mRNA.
RefSeq Summary (NM_004933): This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83542.1, BC008951.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155751, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr16:89,238,163-89,252,600 Size: 14,438 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr16:89,238,240-89,251,882 Size: 13,643 Coding Exon Count: 5 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:89,238,163-89,252,600)mRNA (may differ from genome)Protein (267 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDH15
CDC HuGE Published Literature: CDH15
Positive Disease Associations: Heart Failure
Related Studies:
  1. Heart Failure
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: CDH15
Diseases sorted by gene-association score: autosomal dominant non-syndromic intellectual disability* (117), hypotrichosis, congenital, with juvenile macular dystrophy (12), 16q24.3 microdeletion syndrome (10), deafness, autosomal recessive 89 (9), telogen effluvium (9), mental retardation, x-linked, syndromic 13 (8), kbg syndrome (5), hair disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.64 RPKM in Brain - Cerebellum
Total median expression: 127.63 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.1077-0.378 Picture PostScript Text
3' UTR -288.60718-0.402 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  D83542 - Homo sapiens mRNA for cadherin-15, complete cds.
BC008951 - Homo sapiens cadherin 15, type 1, M-cadherin (myotubule), mRNA (cDNA clone MGC:3599 IMAGE:3027886), complete cds.
DQ893277 - Synthetic construct clone IMAGE:100005907; FLH195874.01X; RZPDo839H03152D cadherin 15, M-cadherin (myotubule) (CDH15) gene, encodes complete protein.
DQ896608 - Synthetic construct Homo sapiens clone IMAGE:100011068; FLH195870.01L; RZPDo839H03151D cadherin 15, M-cadherin (myotubule) (CDH15) gene, encodes complete protein.
JD327063 - Sequence 308087 from Patent EP1572962.
AK308596 - Homo sapiens cDNA, FLJ98637.
AK308631 - Homo sapiens cDNA, FLJ98672.
JD257254 - Sequence 238278 from Patent EP1572962.
LF375155 - JP 2014500723-A/182658: Polycomb-Associated Non-Coding RNAs.
MA610732 - JP 2018138019-A/182658: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04514 - Cell adhesion molecules (CAMs)

-  Other Names for This Gene
  Alternate Gene Symbols: AK308631
UCSC ID: uc010cij.1
RefSeq Accession: NM_004933

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK308631.1
exon count: 5CDS single in 3' UTR: no RNA size: 1587
ORF size: 804CDS single in intron: no Alignment % ID: 99.31
txCdsPredict score: 1807.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 859# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.