Human Gene MAF1 (uc003zbc.1) Description and Page Index
Description: Homo sapiens MAF1 homolog (S. cerevisiae) (MAF1), mRNA. RefSeq Summary (NM_032272): This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.76158.1, SRR3476690.406554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000322428.10/ ENSP00000318604.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr8:145,159,305-145,162,515 Size: 3,211 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr8:145,160,587-145,162,012 Size: 1,426 Coding Exon Count: 7
ID:MAF1_HUMAN DESCRIPTION: RecName: Full=Repressor of RNA polymerase III transcription MAF1 homolog; FUNCTION: Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. SUBUNIT: Interacts with BRF2. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PTM: Phosphorylated at Ser-60, Ser-68 and Ser-75; the major sites of phosphorylation. Nuclear accumulation correlates with a concomitant dephosphorylation. Phosphorylation may attenuate its RNA polymerase III-repressive function. SIMILARITY: Belongs to the MAF1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H063
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000994 RNA polymerase III core binding GO:0001030 RNA polymerase III type 1 promoter DNA binding GO:0001031 RNA polymerase III type 2 promoter DNA binding GO:0001032 RNA polymerase III type 3 promoter DNA binding GO:0050811 GABA receptor binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0016480 negative regulation of transcription from RNA polymerase III promoter