Human Gene HNF4G (uc003yap.1) Description and Page Index
  Description: Homo sapiens hepatocyte nuclear factor 4, gamma (HNF4G), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:76,320,183-76,459,916 Size: 139,734 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr8:76,456,069-76,459,915 Size: 3,847 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:76,320,183-76,459,916)mRNA (may differ from genome)Protein (80 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedStanford SOURCE
TreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q7Z5U9_HUMAN
DESCRIPTION: SubName: Full=HNF4G protein; Flags: Fragment;
SIMILARITY: Belongs to the nuclear hormone receptor family.
SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): HNF4G
CDC HuGE Published Literature: HNF4G
Positive Disease Associations: Body Mass Index , Breath Tests , Cholesterol, HDL , E-Selectin , Echocardiography , Electrocardiography , Glucose , Iron , Lipids , Pancreatic Neoplasms , Stroke , Triglycerides
Related Studies:
  1. Body Mass Index
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  2. Body Mass Index
    Elizabeth K Speliotes et al. Nature genetics 2010, Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index., Nature genetics. [PubMed 20935630]
  3. Breath Tests
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: HNF4G
Diseases sorted by gene-association score: maturity-onset diabetes of the young (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.88 RPKM in Small Intestine - Terminal Ileum
Total median expression: 41.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.20160-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001628 - Znf_hrmn_rcpt
IPR013088 - Znf_NHR/GATA

Pfam Domains:
PF00105 - Zinc finger, C4 type (two domains)

SCOP Domains:
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on Q7Z5U9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC054009 - Homo sapiens hepatocyte nuclear factor 4, gamma, mRNA (cDNA clone IMAGE:6615869), partial cds.
Z49826 - Homo sapiens mRNA for hepatocyte nuclear factor 4 gamma.
BX571750 - Homo sapiens mRNA; cDNA DKFZp686E14224 (from clone DKFZp686E14224).
EU832451 - Synthetic construct Homo sapiens clone HAIB:100067480; DKFZo008A1029 hepatocyte nuclear factor 4, gamma protein (HNF4G) gene, encodes complete protein.
HQ692842 - Homo sapiens hepatocyte nuclear factor 4 gamma (NR2A2) mRNA, complete cds.
BC105009 - Homo sapiens hepatocyte nuclear factor 4, gamma, mRNA (cDNA clone MGC:132669 IMAGE:8144012), complete cds.
BC105011 - Homo sapiens hepatocyte nuclear factor 4, gamma, mRNA (cDNA clone MGC:132671 IMAGE:8144014), complete cds.
JD046458 - Sequence 27482 from Patent EP1572962.
CR542091 - Homo sapiens full open reading frame cDNA clone RZPDo834C0537D for gene HNF4G, hepatocyte nuclear factor 4, gamma; complete cds, without stopcodon.
AB307704 - Homo sapiens NR2A3 mRNA for hepatocyte nuclear factor 4, gamma, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04950 - Maturity onset diabetes of the young

-  Other Names for This Gene
  Alternate Gene Symbols: BC054009, Q7Z5U9, Q7Z5U9_HUMAN
UCSC ID: uc003yap.1
RefSeq Accession: NM_004133
Protein: Q7Z5U9

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC054009.1
exon count: 4CDS single in 3' UTR: no RNA size: 405
ORF size: 240CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 630.00frame shift in genome: no % Coverage: 95.06
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.