Human Gene LY96 (uc003yad.3) Description and Page Index
Description: Homo sapiens lymphocyte antigen 96 (LY96), transcript variant 1, mRNA. RefSeq Summary (NM_015364): This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]. Transcript (Including UTRs) Position: hg19 chr8:74,903,564-74,941,307 Size: 37,744 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr8:74,903,678-74,941,289 Size: 37,612 Coding Exon Count: 5
ID:LY96_HUMAN DESCRIPTION: RecName: Full=Lymphocyte antigen 96; Short=Ly-96; AltName: Full=ESOP-1; AltName: Full=Protein MD-2; Flags: Precursor; FUNCTION: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS. SUBUNIT: Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex. INTERACTION: O00206:TLR4; NbExp=3; IntAct=EBI-1539247, EBI-528701; SUBCELLULAR LOCATION: Secreted, extracellular space. PTM: N-glycosylated; high-mannose.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LY96 CDC HuGE Published Literature: LY96
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6Y9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.