Human Gene TCEB1 (uc003xzx.2) Description and Page Index
Description: Homo sapiens transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1, mRNA. RefSeq Summary (NM_005648): This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]. Transcript (Including UTRs) Position: hg19 chr8:74,857,373-74,884,522 Size: 27,150 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr8:74,858,865-74,872,003 Size: 13,139 Coding Exon Count: 3
ID:ELOC_HUMAN DESCRIPTION: RecName: Full=Transcription elongation factor B polypeptide 1; AltName: Full=Elongin 15 kDa subunit; AltName: Full=Elongin-C; Short=EloC; AltName: Full=RNA polymerase II transcription factor SIII subunit C; AltName: Full=SIII p15; FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). FUNCTION: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. SUBUNIT: Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1 (By similarity). The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1. INTERACTION: Q96G25:MED8; NbExp=3; IntAct=EBI-301231, EBI-394405; Q99619:SPSB2; NbExp=3; IntAct=EBI-301231, EBI-2323209; Q96A44:SPSB4; NbExp=2; IntAct=EBI-301231, EBI-2323233; Q15370:TCEB2; NbExp=3; IntAct=EBI-301231, EBI-301238; P12504:vif (xeno); NbExp=5; IntAct=EBI-301231, EBI-779991; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3. SIMILARITY: Belongs to the SKP1 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TCEB1 CDC HuGE Published Literature: TCEB1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15369
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006511 ubiquitin-dependent protein catabolic process GO:0016032 viral process GO:0016567 protein ubiquitination GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0043687 post-translational protein modification GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
R-HSA-112435 Formation of Elongin BC complex R-HSA-112436 Formation of Elongin complex R-HSA-180555 Association of APOBEC3G:Vif with the Cul5-SCF complex R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-167196 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-1234169 Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha R-HSA-180540 Multi-ubiquitination of APOBEC3G R-HSA-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 R-HSA-8956103 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases R-HSA-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex R-HSA-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-167150 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167076 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167148 TFIIS-mediated recovery of elongation from arrest R-HSA-167459 Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex) R-HSA-167090 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167192 Pol II elongation complex moves on the HIV-1 template as transcript elongates R-HSA-167181 Addition of nucleotides leads to HIV-1 transcript elongation R-HSA-167197 Separation of elongating HIV-1 transcript from template R-HSA-167481 Abortive termination of HIV-1 elongation after arrest R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes R-HSA-1234172 Nuclear VBC complex ubiquitinylates HIF-alpha R-HSA-1234183 Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha R-HSA-8956106 VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes R-HSA-1234163 Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha R-HSA-1234173 Cytosolic PHD2,3 hydroxylates proline residues on HIF3A R-HSA-1234177 Cytosolic PHD2,3 hydroxylates proline residues on HIF1A R-HSA-1234179 Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73857 RNA Polymerase II Transcription R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-74160 Gene expression (Transcription) R-HSA-162909 Host Interactions of HIV factors R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-376176 Signaling by ROBO receptors R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-167287 HIV elongation arrest and recovery R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-167172 Transcription of the HIV genome R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen R-HSA-162906 HIV Infection R-HSA-597592 Post-translational protein modification R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-422475 Axon guidance R-HSA-167169 HIV Transcription Elongation R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-2262749 Cellular response to hypoxia R-HSA-5663205 Infectious disease R-HSA-392499 Metabolism of proteins R-HSA-1280218 Adaptive Immune System R-HSA-1266738 Developmental Biology R-HSA-212436 Generic Transcription Pathway R-HSA-162587 HIV Life Cycle R-HSA-2262752 Cellular responses to stress R-HSA-1643685 Disease R-HSA-168256 Immune System R-HSA-8953897 Cellular responses to external stimuli