Human Gene STAU2 (uc003xzm.3) Description and Page Index
  Description: Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 1, mRNA.
RefSeq Summary (NM_001164380): Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Transcript (Including UTRs)
   Position: hg19 chr8:74,332,604-74,659,162 Size: 326,559 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr8:74,333,607-74,621,380 Size: 287,774 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:74,332,604-74,659,162)mRNA (may differ from genome)Protein (570 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIneXtProtOMIM
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: STAU2_HUMAN
DESCRIPTION: RecName: Full=Double-stranded RNA-binding protein Staufen homolog 2;
FUNCTION: RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).
SUBUNIT: Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
INTERACTION: Q96C10:DHX58; NbExp=2; IntAct=EBI-722938, EBI-744193; P19525:EIF2AK2; NbExp=2; IntAct=EBI-722938, EBI-640775;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1- dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity).
DOMAIN: The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity).
SIMILARITY: Contains 4 DRBM (double-stranded RNA-binding) domains.
SEQUENCE CAUTION: Sequence=BAA91766.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14522.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STAU2
CDC HuGE Published Literature: STAU2
Positive Disease Associations: Body Mass Index , Body Weight Changes , Multiple Sclerosis
Related Studies:
  1. Body Mass Index
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  2. Body Mass Index
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  3. Body Mass Index
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.11 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 217.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -118.66341-0.348 Picture PostScript Text
3' UTR -280.191003-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001159 - Ds-RNA-bd
IPR014720 - dsRNA-bd-like

Pfam Domains:
PF00035 - Double-stranded RNA binding motif
PF16482 - Staufen C-terminal domain

SCOP Domains:
54768 - dsRNA-binding domain-like

ModBase Predicted Comparative 3D Structure on Q9NUL3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005874 microtubule
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AF459097 - Homo sapiens double-stranded RNA-binding protein Staufen2 long isoform (STAU2) mRNA, complete cds; alternatively spliced.
AF459098 - Homo sapiens double-stranded RNA-binding protein Staufen2 short isoform (STAU2) mRNA, complete cds; alternatively spliced.
AK002152 - Homo sapiens cDNA FLJ11290 fis, clone PLACE1009622, weakly similar to MATERNAL EFFECT PROTEIN STAUFEN.
BC008369 - Homo sapiens staufen, RNA binding protein, homolog 2 (Drosophila), mRNA (cDNA clone MGC:12191 IMAGE:3682739), complete cds.
AK293496 - Homo sapiens cDNA FLJ58766 complete cds, highly similar to Double-stranded RNA-binding protein Staufen homolog 2.
AK303104 - Homo sapiens cDNA FLJ57245 complete cds, highly similar to Double-stranded RNA-binding protein Staufen homolog 2.
EU176423 - Synthetic construct Homo sapiens clone IMAGE:100006501; FLH193361.01X; RZPDo839E06252D staufen, RNA binding protein, homolog 2 (Drosophila) (STAU2) gene, encodes complete protein.
DQ896332 - Synthetic construct Homo sapiens clone IMAGE:100010792; FLH193354.01L; RZPDo839F0568D staufen, RNA binding protein, homolog 2 (Drosophila) (STAU2) gene, encodes complete protein.
AB210014 - Homo sapiens mRNA for STAU2 variant protein, clone: fj01677.
Y19062 - Homo sapiens mRNA for 39k3 protein.
BC110447 - Homo sapiens staufen, RNA binding protein, homolog 2 (Drosophila), mRNA (cDNA clone MGC:119606 IMAGE:40009098), complete cds.
BC110448 - Homo sapiens cDNA clone IMAGE:40009099, containing frame-shift errors.
CR627442 - Homo sapiens mRNA; cDNA DKFZp781K0371 (from clone DKFZp781K0371).
AK294466 - Homo sapiens cDNA FLJ58771 complete cds, highly similar to Double-stranded RNA-binding protein Staufen homolog 2.
AK290141 - Homo sapiens cDNA FLJ78317 complete cds, highly similar to Homo sapiens staufen, RNA binding protein, homolog 2 (Drosophila) (STAU2), mRNA.
AK293729 - Homo sapiens cDNA FLJ57953 complete cds, highly similar to Double-stranded RNA-binding protein Staufen homolog 2.
AK314617 - Homo sapiens cDNA, FLJ95458, Homo sapiens staufen, RNA binding protein, homolog 2 (Drosophila)(STAU2), mRNA.
AB384369 - Synthetic construct DNA, clone: pF1KSDB0032, Homo sapiens STAU2 gene for double-stranded RNA-binding protein Staufen homolog 2, complete cds, without stop codon, in Flexi system.
KJ898656 - Synthetic construct Homo sapiens clone ccsbBroadEn_08050 STAU2 gene, encodes complete protein.
AK307841 - Homo sapiens cDNA, FLJ97789.
BC008370 - Homo sapiens staufen, RNA binding protein, homolog 2 (Drosophila), mRNA (cDNA clone IMAGE:3510987), complete cds.
AL079285 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1293175.
BC071766 - Homo sapiens cDNA clone IMAGE:4047010, partial cds.
AK001576 - Homo sapiens cDNA FLJ10714 fis, clone NT2RP3000994, weakly similar to MATERNAL EFFECT PROTEIN STAUFEN.
AL079288 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 301322.
AK023314 - Homo sapiens cDNA FLJ13252 fis, clone OVARC1000746, weakly similar to MATERNAL EFFECT PROTEIN STAUFEN.
JD193639 - Sequence 174663 from Patent EP1572962.
KJ902448 - Synthetic construct Homo sapiens clone ccsbBroadEn_11842 STAU2 gene, encodes complete protein.
JD422190 - Sequence 403214 from Patent EP1572962.
JD429875 - Sequence 410899 from Patent EP1572962.
AK126149 - Homo sapiens cDNA FLJ44161 fis, clone THYMU2033070.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PF26, NM_001164380, NP_001157855, Q6AHY7, Q96HM0, Q96HM1, Q9NUL3, Q9NVI5, Q9UGG6, STAU2_HUMAN
UCSC ID: uc003xzm.3
RefSeq Accession: NM_001164380
Protein: Q9NUL3 (aka STAU2_HUMAN)
CCDS: CCDS55247.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001164380.1
exon count: 15CDS single in 3' UTR: no RNA size: 3065
ORF size: 1713CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3550.50frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.