Human Gene GPR171 (uc003eyq.4) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 171 (GPR171), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:150,915,619-150,920,988 Size: 5,370 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr3:150,916,214-150,917,173 Size: 960 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:150,915,619-150,920,988)mRNA (may differ from genome)Protein (319 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GP171_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 171; AltName: Full=G-protein coupled receptor H963;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.11 RPKM in Spleen
Total median expression: 31.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.55240-0.256 Picture PostScript Text
3' UTR -98.41595-0.165 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on O14626
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0045028 G-protein coupled purinergic nucleotide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0045638 negative regulation of myeloid cell differentiation

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC036815 - Homo sapiens G protein-coupled receptor 171, mRNA (cDNA clone MGC:46113 IMAGE:5747378), complete cds.
JD298144 - Sequence 279168 from Patent EP1572962.
JD504173 - Sequence 485197 from Patent EP1572962.
AF002986 - Homo sapiens platelet activating receptor homolog (H963) mRNA, complete cds.
JD314602 - Sequence 295626 from Patent EP1572962.
DQ890941 - Synthetic construct clone IMAGE:100003571; FLH167734.01X; RZPDo839E0890D G protein-coupled receptor 171 (GPR171) gene, encodes complete protein.
KJ898742 - Synthetic construct Homo sapiens clone ccsbBroadEn_08136 GPR171 gene, encodes complete protein.
DQ894101 - Synthetic construct Homo sapiens clone IMAGE:100008561; FLH167730.01L; RZPDo839E0889D G protein-coupled receptor 171 (GPR171) gene, encodes complete protein.
CU691428 - Synthetic construct Homo sapiens gateway clone IMAGE:100016700 5' read GPR171 mRNA.
JD213865 - Sequence 194889 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DNJ4, GP171_HUMAN, H963, NM_013308, NP_037440, O14626, Q8IV06
UCSC ID: uc003eyq.4
RefSeq Accession: NM_013308
Protein: O14626 (aka GP171_HUMAN or G171_HUMAN)
CCDS: CCDS3155.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_013308.3
exon count: 3CDS single in 3' UTR: no RNA size: 1862
ORF size: 960CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2069.00frame shift in genome: no % Coverage: 96.40
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.