Human Gene DZIP3 (uc003dxf.1) Description and Page Index
  Description: Homo sapiens DAZ interacting zinc finger protein 3 (DZIP3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:108,321,698-108,410,234 Size: 88,537 Total Exon Count: 32 Strand: +
Coding Region
   Position: hg19 chr3:108,324,254-108,409,744 Size: 85,491 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:108,321,698-108,410,234)mRNA (may differ from genome)Protein (1208 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase DZIP3; EC=6.3.2.-; AltName: Full=DAZ-interacting protein 3; AltName: Full=RNA-binding ubiquitin ligase of 138 kDa; Short=hRUL138;
FUNCTION: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Interacts with DAZ proteins.
INTERACTION: Q9H0E2:TOLLIP; NbExp=2; IntAct=EBI-948630, EBI-74615;
TISSUE SPECIFICITY: Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=AAH39018.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH56674.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAK69484.1; Type=Frameshift; Positions=1127; Sequence=BAA31650.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.65 RPKM in Pituitary
Total median expression: 268.12 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.10129-0.195 Picture PostScript Text
3' UTR -112.31490-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001841 - Znf_RING

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF12678 - RING-H2 zinc finger domain
PF13639 - Ring finger domain
PF13923 - Zinc finger, C3HC4 type (RING finger)

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q86Y13
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0019902 phosphatase binding
GO:0031593 polyubiquitin binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
GO:0061630 ubiquitin protein ligase activity
GO:1990381 ubiquitin-specific protease binding

Biological Process:
GO:0000209 protein polyubiquitination
GO:0016567 protein ubiquitination
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response

Cellular Component:
GO:0000836 Hrd1p ubiquitin ligase complex
GO:0005737 cytoplasm
GO:0036513 Derlin-1 retrotranslocation complex
GO:0044322 endoplasmic reticulum quality control compartment

-  Descriptions from all associated GenBank mRNAs
  AY227654 - Homo sapiens clone DKFZp586C1754Q3 RNA-binding RING-H2 protein-ubiquitin ligase short isoform mRNA, complete cds; alternatively spliced.
AK023138 - Homo sapiens cDNA FLJ13076 fis, clone NT2RP3001943, highly similar to Ubiquitin ligase protein DZIP3 (EC 6.3.2.-).
AK297451 - Homo sapiens cDNA FLJ58022 complete cds, highly similar to Ubiquitin ligase protein DZIP3 (EC 6.3.2.-).
BC063882 - Homo sapiens DAZ interacting protein 3, zinc finger, mRNA (cDNA clone MGC:75477 IMAGE:30387514), complete cds.
AB014575 - Homo sapiens KIAA0675 mRNA for KIAA0675 protein.
HQ258001 - Synthetic construct Homo sapiens clone IMAGE:100072310 DAZ interacting protein 3, zinc finger (DZIP3) (DZIP3) gene, encodes complete protein.
KJ892829 - Synthetic construct Homo sapiens clone ccsbBroadEn_02223 DZIP3 gene, encodes complete protein.
AB463003 - Synthetic construct DNA, clone: pF1KA0675, Homo sapiens DZIP3 gene for DAZ interacting protein 3, zinc finger, without stop codon, in Flexi system.
GQ129281 - Synthetic construct Homo sapiens clone HAIB:100068655; DKFZo004B0436 DAZ interacting protein 3, zinc finger protein (DZIP3) gene, partial cds.
GQ129282 - Synthetic construct Homo sapiens clone HAIB:100068559; DKFZo008B0435 DAZ interacting protein 3, zinc finger protein (DZIP3) gene, complete cds.
AK294967 - Homo sapiens cDNA FLJ57977 complete cds, highly similar to Ubiquitin ligase protein DZIP3 (EC 6.3.2.-).
AK303942 - Homo sapiens cDNA FLJ58223 complete cds, highly similar to Ubiquitin ligase protein DZIP3 (EC 6.3.2.-).
AY227652 - Homo sapiens clone ICRFp512H14173Q2 RNA-binding RING-H2 protein-ubiquitin ligase mRNA, partial cds.
AF279370 - Homo sapiens DZIP3 mRNA, partial cds.
AY495710 - Homo sapiens UURF2 ubiquitin ligase mRNA, partial cds.
AK023389 - Homo sapiens cDNA FLJ13327 fis, clone OVARC1001767, highly similar to Homo sapiens mRNA for KIAA0675 protein.
BC056674 - Homo sapiens DAZ interacting protein 3, zinc finger, mRNA (cDNA clone IMAGE:6617869), partial cds.
BC039018 - Homo sapiens DAZ interacting protein 3, zinc finger, mRNA (cDNA clone IMAGE:6046587), partial cds.
AY227651 - Homo sapiens clone NIII RNA-binding RING-H2 protein-ubiquitin ligase mRNA, partial cds.
BC012631 - Homo sapiens zinc finger DAZ interacting protein 3, mRNA (cDNA clone IMAGE:4096020), with apparent retained intron.
JD301824 - Sequence 282848 from Patent EP1572962.
JD079248 - Sequence 60272 from Patent EP1572962.
AY227653 - Homo sapiens clone ICRFp512B2269Q2 RNA-binding RING-H2 protein-ubiquitin ligase precursor RNA, partial cds.
JD557016 - Sequence 538040 from Patent EP1572962.
JD101706 - Sequence 82730 from Patent EP1572962.
JD535259 - Sequence 516283 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86Y13 (Reactome details) participates in the following event(s):

R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: AB014575, B3KN01, DZIP3_HUMAN, KIAA0675, NM_014648, NP_055463, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
UCSC ID: uc003dxf.1
RefSeq Accession: NM_014648
Protein: Q86Y13 (aka DZIP3_HUMAN or DZP3_HUMAN)
CCDS: CCDS2952.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AB014575.1
exon count: 32CDS single in 3' UTR: no RNA size: 4246
ORF size: 3627CDS single in intron: no Alignment % ID: 99.98
txCdsPredict score: 6762.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 484# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.