Human Gene MED15 (uc002zsr.3) Description and Page Index
  Description: Homo sapiens mediator complex subunit 15 (MED15), transcript variant 2, mRNA.
RefSeq Summary (NM_015889): The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Transcript (Including UTRs)
   Position: hg19 chr22:20,861,905-20,941,919 Size: 80,015 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr22:20,891,414-20,940,991 Size: 49,578 Coding Exon Count: 16 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr22:20,861,905-20,941,919)mRNA (may differ from genome)Protein (722 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MED15
CDC HuGE Published Literature: MED15
Positive Disease Associations: Arteries
Related Studies:
  1. Arteries
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: MED15
Diseases sorted by gene-association score: chromosome 22q11.2 microduplication syndrome (2), velocardiofacial syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.84 RPKM in Spleen
Total median expression: 1050.60 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.50128-0.418 Picture PostScript Text
3' UTR -393.40928-0.424 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019087 - Mediator_Med15_met

Pfam Domains:
PF09606 - ARC105 or Med15 subunit of Mediator complex non-fungal

ModBase Predicted Comparative 3D Structure on G3V1P5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001104 RNA polymerase II transcription cofactor activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0016592 mediator complex

-  Descriptions from all associated GenBank mRNAs
  AK315540 - Homo sapiens cDNA, FLJ96606.
AK074268 - Homo sapiens cDNA FLJ23688 fis, clone HEP10127.
JD592517 - Sequence 240 from Patent WO2015022211.
JD592519 - Sequence 242 from Patent WO2015022211.
LF385108 - JP 2014500723-A/192611: Polycomb-Associated Non-Coding RNAs.
AF056191 - Homo sapiens TPA inducible protein mRNA, complete cds.
AK297284 - Homo sapiens cDNA FLJ59342 complete cds, highly similar to Positive cofactor 2glutamine/Q-rich-associated protein.
AK090465 - Homo sapiens mRNA for FLJ00386 protein.
AK297789 - Homo sapiens cDNA FLJ59938 complete cds, highly similar to Positive cofactor 2glutamine/Q-rich-associated protein.
BC003078 - Homo sapiens mediator complex subunit 15, mRNA (cDNA clone IMAGE:3504608), partial cds.
BC013985 - Homo sapiens mediator complex subunit 15, mRNA (cDNA clone MGC:20267 IMAGE:3506327), complete cds.
CR456537 - Homo sapiens PCQAP full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.PCQAP.V2).
AB463109 - Synthetic construct DNA, clone: pF1KF0386, Homo sapiens MED15 gene for mediator complex subunit 15, without stop codon, in Flexi system.
CU013425 - Homo sapiens PCQAP, mRNA (cDNA clone IMAGE:100000394), complete cds, without stop codon, in Gateway system.
CU013137 - Homo sapiens PCQAP, mRNA (cDNA clone IMAGE:100000490), complete cds, with stop codon, in Gateway system.
AF328769 - Homo sapiens PC2-glutamine-rich-associated protein (PCQAP) mRNA, complete cds.
AK294734 - Homo sapiens cDNA FLJ58758 complete cds, highly similar to Positive cofactor 2glutamine/Q-rich-associated protein.
AK294540 - Homo sapiens cDNA FLJ58080 complete cds, highly similar to Positive cofactor 2glutamine/Q-rich-associated protein.
AK126208 - Homo sapiens cDNA FLJ44220 fis, clone THYMU3004866, moderately similar to Homo sapiens PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein (PCQAP).
BC017110 - Homo sapiens PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein, mRNA (cDNA clone IMAGE:3604453).
U80745 - Homo sapiens CTG7a mRNA, partial cds.
LF338566 - JP 2014500723-A/146069: Polycomb-Associated Non-Coding RNAs.
AK074230 - Homo sapiens cDNA FLJ23650 fis, clone COL07911, highly similar to TPA inducible gene-1.
LF338565 - JP 2014500723-A/146068: Polycomb-Associated Non-Coding RNAs.
AK124276 - Homo sapiens cDNA FLJ42282 fis, clone TLIVE2004320, highly similar to Positive cofactor 2 glutamine/Q-rich-associated protein.
AK124925 - Homo sapiens cDNA FLJ42935 fis, clone BRSSN2014299, highly similar to Positive cofactor 2glutamine/Q-rich-associated protein.
AL832151 - Homo sapiens mRNA; cDNA DKFZp686A2214 (from clone DKFZp686A2214).
BC007529 - Homo sapiens mediator complex subunit 15, mRNA (cDNA clone IMAGE:3350171), partial cds.
BC005027 - Homo sapiens cDNA clone IMAGE:2822900, with apparent retained intron.
AK000003 - Homo sapiens mRNA for FLJ00003 protein, partial cds.
AL832923 - Homo sapiens mRNA; cDNA DKFZp762B1216 (from clone DKFZp762B1216).
JD482345 - Sequence 463369 from Patent EP1572962.
JD255382 - Sequence 236406 from Patent EP1572962.
KF274544 - Homo sapiens minisatellite 33.15 tagged transcript pAKT-32 sequence.
KF274593 - Homo sapiens minisatellite MN3 tagged transcript pAST-30 sequence.
KJ806665 - Homo sapiens clone pSG_33.15_T19 satellite sequence.
JD131837 - Sequence 112861 from Patent EP1572962.
JD222380 - Sequence 203404 from Patent EP1572962.
JD217743 - Sequence 198767 from Patent EP1572962.
JD126240 - Sequence 107264 from Patent EP1572962.
MA620685 - JP 2018138019-A/192611: Polycomb-Associated Non-Coding RNAs.
MA574143 - JP 2018138019-A/146069: Polycomb-Associated Non-Coding RNAs.
MA574142 - JP 2018138019-A/146068: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC003078, G3V1P5, G3V1P5_HUMAN, hCG_41277, PCQAP
UCSC ID: uc002zsr.3
RefSeq Accession: NM_015889
Protein: G3V1P5 CCDS: CCDS13781.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC003078.1
exon count: 17CDS single in 3' UTR: no RNA size: 3240
ORF size: 2169CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 4465.00frame shift in genome: no % Coverage: 99.07
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.