Human Gene MGAT5B (uc002jti.3) Description and Page Index
Description: Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (MGAT5B), transcript variant 2, mRNA.
RefSeq Summary (NM_198955): The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 184.108.40.206) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008].
Transcript (Including UTRs)
Position: hg19 chr17:74,868,729-74,946,471 Size: 77,743 Total Exon Count: 16 Strand: +
Position: hg19 chr17:74,868,832-74,944,920 Size: 76,089 Coding Exon Count: 16
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
MGAT5B CDC HuGE Published Literature:
MGAT5B Positive Disease Associations: Hemoglobin A, Glycosylated
, Lipoproteins, LDL
Hemoglobin A, Glycosylated Andrew D Paterson et al. Diabetes 2010, A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose., Diabetes.
A major locus for A1C and glucose in individuals with diabetes is near SORCS1. This may influence the design and analysis of genetic studies attempting to identify risk factors for long-term diabetic complications.
Lipoproteins, LDL , , .
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF15024 - Glycosyltransferase family 18
ModBase Predicted Comparative 3D Structure on Q3V5L5-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK057861 - Homo sapiens cDNA FLJ25132 fis, clone CBR06774. AB235153 - Homo sapiens KIAA2008 mRNA for hypothetical protein. BC041577 - Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B, mRNA (cDNA clone IMAGE:4636485). BC062354 - Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B, mRNA (cDNA clone IMAGE:4643626), complete cds. AB109185 - Homo sapiens GnT-IX mRNA for N-Acetylglucosaminyltransferase IX, complete cds. AB384348 - Synthetic construct DNA, clone: pF1KSDA2008, Homo sapiens MGAT5B gene for alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B, complete cds, without stop codon, in Flexi system. AB114297 - Homo sapiens hGnTVb mRNA for UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase b, complete cds. BC144361 - Homo sapiens cDNA clone IMAGE:9052882, containing frame-shift errors. BC156823 - Synthetic construct Homo sapiens clone IMAGE:100062526, MGC:190543 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (MGAT5B) mRNA, encodes complete protein. JD128217 - Sequence 109241 from Patent EP1572962. JD139262 - Sequence 120286 from Patent EP1572962. JD213717 - Sequence 194741 from Patent EP1572962. JD408409 - Sequence 389433 from Patent EP1572962. JD358436 - Sequence 339460 from Patent EP1572962. JD219428 - Sequence 200452 from Patent EP1572962. JD513106 - Sequence 494130 from Patent EP1572962. JD119460 - Sequence 100484 from Patent EP1572962. JD483514 - Sequence 464538 from Patent EP1572962. JD454692 - Sequence 435716 from Patent EP1572962. BC036948 - Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B, mRNA (cDNA clone IMAGE:5503346), with apparent retained intron. BC063862 - Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B, mRNA (cDNA clone IMAGE:6181037), complete cds. KJ903839 - Synthetic construct Homo sapiens clone ccsbBroadEn_13233 MGAT5B gene, encodes complete protein. AK123189 - Homo sapiens cDNA FLJ41195 fis, clone BRACE2045596, weakly similar to CTD-BINDING SR-LIKE PROTEIN RA4. JD541797 - Sequence 522821 from Patent EP1572962. JD086240 - Sequence 67264 from Patent EP1572962. JD422353 - Sequence 403377 from Patent EP1572962. JD462856 - Sequence 443880 from Patent EP1572962. JD260330 - Sequence 241354 from Patent EP1572962. JD443320 - Sequence 424344 from Patent EP1572962. JD256327 - Sequence 237351 from Patent EP1572962. JD459295 - Sequence 440319 from Patent EP1572962. JD040210 - Sequence 21234 from Patent EP1572962. JD475830 - Sequence 456854 from Patent EP1572962. JD106760 - Sequence 87784 from Patent EP1572962. JD136678 - Sequence 117702 from Patent EP1572962. JD294322 - Sequence 275346 from Patent EP1572962. JD256283 - Sequence 237307 from Patent EP1572962. JD566264 - Sequence 547288 from Patent EP1572962. JD177900 - Sequence 158924 from Patent EP1572962. JD306596 - Sequence 287620 from Patent EP1572962. JD056050 - Sequence 37074 from Patent EP1572962. JD376285 - Sequence 357309 from Patent EP1572962. JD554259 - Sequence 535283 from Patent EP1572962. JD374218 - Sequence 355242 from Patent EP1572962. JD564918 - Sequence 545942 from Patent EP1572962. JD190855 - Sequence 171879 from Patent EP1572962. JD405930 - Sequence 386954 from Patent EP1572962. JD375779 - Sequence 356803 from Patent EP1572962. JD458154 - Sequence 439178 from Patent EP1572962. JD226648 - Sequence 207672 from Patent EP1572962. JD102430 - Sequence 83454 from Patent EP1572962. JD129748 - Sequence 110772 from Patent EP1572962. JD163704 - Sequence 144728 from Patent EP1572962. JD449510 - Sequence 430534 from Patent EP1572962. JD295046 - Sequence 276070 from Patent EP1572962. JD180599 - Sequence 161623 from Patent EP1572962. JD092846 - Sequence 73870 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00510 - N-Glycan biosynthesis hsa01100 - Metabolic pathways
Other Names for This Gene
Gene Model Information
16 CDS single in 3' UTR:
2406 CDS single in intron:
Alignment % ID:
4912.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
204 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.