Human Gene TUBB4Q (uc002fqp.4) Description and Page Index
  Description: SubName: Full=Beta-tubulin 4Q isoform 1; Flags: Fragment;
Transcript (Including UTRs)
   Position: hg19 chr16:90,159,562-90,162,762 Size: 3,201 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr16:90,160,775-90,162,011 Size: 1,237 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:90,159,562-90,162,762)mRNA (may differ from genome)Protein (212 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaCGAPEnsembl
ExonPrimerGeneCardsMGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Beta-tubulin 4Q isoform 1; Flags: Fragment;
FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).
SUBUNIT: Dimer of alpha and beta chains (By similarity).
SIMILARITY: Belongs to the tubulin family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.52 RPKM in Ovary
Total median expression: 3.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -206.52725-0.285 Picture PostScript Text
3' UTR -282.57751-0.376 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002453 - Beta_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain

SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like

ModBase Predicted Comparative 3D Structure on I0CMK4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

Biological Process:
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process

Cellular Component:
GO:0005874 microtubule

-  Descriptions from all associated GenBank mRNAs
  BC014971 - Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.
JD080540 - Sequence 61564 from Patent EP1572962.
JD173743 - Sequence 154767 from Patent EP1572962.
JD500711 - Sequence 481735 from Patent EP1572962.
BC101272 - Homo sapiens cDNA clone IMAGE:40024144, **** WARNING: chimeric clone ****.
BC139719 - Homo sapiens cDNA clone IMAGE:40024149.
JD128873 - Sequence 109897 from Patent EP1572962.
JD406993 - Sequence 388017 from Patent EP1572962.
JD474669 - Sequence 455693 from Patent EP1572962.
JD427449 - Sequence 408473 from Patent EP1572962.
JD497922 - Sequence 478946 from Patent EP1572962.
JD178727 - Sequence 159751 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC014971, I0CMK4, I0CMK4_HUMAN, uc002fqp.3
UCSC ID: uc002fqp.4
Representative RNA: BC014971
Protein: I0CMK4

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC014971.1
exon count: 3CDS single in 3' UTR: no RNA size: 2131
ORF size: 639CDS single in intron: no Alignment % ID: 99.57
txCdsPredict score: 907.00frame shift in genome: no % Coverage: 99.20
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.