Human Gene GAS8 (uc002fqh.2) Description and Page Index
Description: Homo sapiens growth arrest-specific 8 (GAS8), transcript variant 2, non-coding RNA. RefSeq Summary (NM_001481): This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]. Transcript (Including UTRs) Position: hg19 chr16:90,086,069-90,111,379 Size: 25,311 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr16:90,097,866-90,109,753 Size: 11,888 Coding Exon Count: 9
ID:GAS8_HUMAN DESCRIPTION: RecName: Full=Growth arrest-specific protein 8; Short=GAS-8; AltName: Full=Growth arrest-specific protein 11; Short=GAS-11; FUNCTION: Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). INTERACTION: O76071:CIAO1; NbExp=1; IntAct=EBI-1052570, EBI-725145; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, flagellum basal body (By similarity). Golgi apparatus (By similarity). Note=Associates with microtubules (By similarity). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity). TISSUE SPECIFICITY: Expressed in the heart, skeletal muscle, pancreas and liver. Weakly or not expressed in brain, placenta, lung and kidney. SIMILARITY: Belongs to the GAS8 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GAS8 CDC HuGE Published Literature: GAS8 Positive Disease Associations: Heart Failure Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF13851 - Growth-arrest specific micro-tubule binding
ModBase Predicted Comparative 3D Structure on O95995
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.