Human Gene CDK10 (uc002fof.3) Description and Page Index
Description: Homo sapiens cyclin-dependent kinase 10 (CDK10), transcript variant c, mRNA.
RefSeq Summary (NM_001098533): The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Transcript (Including UTRs)
Position: hg19 chr16:89,753,076-89,762,772 Size: 9,697 Total Exon Count: 13 Strand: +
Position: hg19 chr16:89,757,014-89,762,100 Size: 5,087 Coding Exon Count: 11
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
CDK10 CDC HuGE Published Literature:
CDK10 Positive Disease Associations: Hair Color
, Heart Failure
Hair Color Jiali Han et al. PLoS genetics 2008, A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation., PLoS genetics.
Heart Failure , , .
Melanoma Jennifer H Barrett et al. Nature genetics 2011, Genome-wide association study identifies three new melanoma susceptibility loci., Nature genetics.
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MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q15131-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK131531 - Homo sapiens cDNA FLJ16760 fis, clone BRACE3050764, highly similar to Cell division protein kinase 10 (EC 184.108.40.206). AK298386 - Homo sapiens cDNA FLJ59580 complete cds, highly similar to Cell division protein kinase 10 (EC 220.127.116.11). L33264 - Homo sapiens CDC2-related protein kinase (PISSLRE) mRNA, complete cds. AK075036 - Homo sapiens cDNA FLJ90555 fis, clone OVARC1000916, highly similar to Cell division protein kinase 10 (EC 18.104.22.168). AK295397 - Homo sapiens cDNA FLJ53790 complete cds, highly similar to Cell division protein kinase 10 (EC 22.214.171.124). AB209829 - Homo sapiens mRNA for cyclin-dependent kinase 10 isoform 3 variant protein. BC017342 - Homo sapiens cyclin-dependent kinase 10, mRNA (cDNA clone MGC:29611 IMAGE:4865641), complete cds. AK292351 - Homo sapiens cDNA FLJ78380 complete cds, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10, mRNA. BC093028 - Homo sapiens cDNA clone IMAGE:30528614. AK296631 - Homo sapiens cDNA FLJ52672 complete cds, highly similar to Cell division protein kinase 10 (EC 126.96.36.199). AK290485 - Homo sapiens cDNA FLJ75138 complete cds, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10 (CDK10), transcript variant 3, mRNA. AF153430 - Homo sapiens cyclin-dependent kinase related protein (CDK10) mRNA, splice variant, complete cds. AK312016 - Homo sapiens cDNA, FLJ92291, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10 (CDK10), transcript variant 3, mRNA. BC025301 - Homo sapiens cyclin-dependent kinase 10, mRNA (cDNA clone MGC:39266 IMAGE:4637860), complete cds. BC032704 - Homo sapiens cDNA clone IMAGE:5247509, with apparent retained intron. X78342 - H.sapiens PISSLRE mRNA. CU675952 - Synthetic construct Homo sapiens gateway clone IMAGE:100022382 5' read CDK10 mRNA. AB462997 - Synthetic construct DNA, clone: pF1KB8433, Homo sapiens CDK10 gene for cyclin-dependent kinase 10, without stop codon, in Flexi system. AM392903 - Synthetic construct Homo sapiens clone IMAGE:100002691 for hypothetical protein (CDK10 gene). KJ892561 - Synthetic construct Homo sapiens clone ccsbBroadEn_01955 CDK10 gene, encodes complete protein. KJ905356 - Synthetic construct Homo sapiens clone ccsbBroadEn_14903 CDK10 gene, encodes complete protein. AM393177 - Synthetic construct Homo sapiens clone IMAGE:100002937 for hypothetical protein (CDK10 gene). AM393204 - Synthetic construct Homo sapiens clone IMAGE:100002938 for hypothetical protein (CDK10 gene). EU832413 - Synthetic construct Homo sapiens clone HAIB:100067442; DKFZo004F0228 cyclin-dependent kinase 10 protein (CDK10) gene, encodes complete protein. EU832328 - Synthetic construct Homo sapiens clone HAIB:100067357; DKFZo008F0227 cyclin-dependent kinase 10 protein (CDK10) gene, encodes complete protein. KJ905968 - Synthetic construct Homo sapiens clone ccsbBroadEn_15638 CDK10 gene, encodes complete protein. JD424052 - Sequence 405076 from Patent EP1572962. JD540678 - Sequence 521702 from Patent EP1572962. JD044515 - Sequence 25539 from Patent EP1572962. JD105151 - Sequence 86175 from Patent EP1572962. JD237875 - Sequence 218899 from Patent EP1572962. JD353956 - Sequence 334980 from Patent EP1572962. LF208351 - JP 2014500723-A/15854: Polycomb-Associated Non-Coding RNAs. LF375189 - JP 2014500723-A/182692: Polycomb-Associated Non-Coding RNAs. JD156257 - Sequence 137281 from Patent EP1572962. JD121092 - Sequence 102116 from Patent EP1572962. LF375191 - JP 2014500723-A/182694: Polycomb-Associated Non-Coding RNAs. JD292011 - Sequence 273035 from Patent EP1572962. JD448432 - Sequence 429456 from Patent EP1572962. LF375192 - JP 2014500723-A/182695: Polycomb-Associated Non-Coding RNAs. JD361604 - Sequence 342628 from Patent EP1572962. JD460328 - Sequence 441352 from Patent EP1572962. JD322376 - Sequence 303400 from Patent EP1572962. JD472016 - Sequence 453040 from Patent EP1572962. JD470877 - Sequence 451901 from Patent EP1572962. JD310565 - Sequence 291589 from Patent EP1572962. JD391382 - Sequence 372406 from Patent EP1572962. JD168876 - Sequence 149900 from Patent EP1572962. JD040456 - Sequence 21480 from Patent EP1572962. JD163961 - Sequence 144985 from Patent EP1572962. JD157502 - Sequence 138526 from Patent EP1572962. JD534562 - Sequence 515586 from Patent EP1572962. JD086307 - Sequence 67331 from Patent EP1572962. JD545912 - Sequence 526936 from Patent EP1572962. LF375194 - JP 2014500723-A/182697: Polycomb-Associated Non-Coding RNAs. JD480764 - Sequence 461788 from Patent EP1572962. JD278194 - Sequence 259218 from Patent EP1572962. JD045838 - Sequence 26862 from Patent EP1572962. JD443325 - Sequence 424349 from Patent EP1572962. JD274061 - Sequence 255085 from Patent EP1572962. JD051376 - Sequence 32400 from Patent EP1572962. MA443928 - JP 2018138019-A/15854: Polycomb-Associated Non-Coding RNAs. MA610766 - JP 2018138019-A/182692: Polycomb-Associated Non-Coding RNAs. MA610768 - JP 2018138019-A/182694: Polycomb-Associated Non-Coding RNAs. MA610769 - JP 2018138019-A/182695: Polycomb-Associated Non-Coding RNAs. MA610771 - JP 2018138019-A/182697: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: NM_001098533, NP_001092003, Q15131-3 UCSC ID: uc002fof.3 RefSeq Accession: NM_001098533
Protein: , splice isoform of Q15131-3 Q15131
Gene Model Information
13 CDS single in 3' UTR:
852 CDS single in intron:
Alignment % ID:
1754.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.