Human Gene CDK10 (uc002fob.2) Description and Page Index
  Description: Homo sapiens cyclin-dependent kinase 10 (CDK10), transcript variant f, non-coding RNA.
RefSeq Summary (NR_027703): The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Transcript (Including UTRs)
   Position: hg19 chr16:89,753,076-89,761,221 Size: 8,146 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr16:89,757,014-89,760,813 Size: 3,800 Coding Exon Count: 6 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:89,753,076-89,761,221)mRNA (may differ from genome)Protein (185 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsH-INVHGNC
LynxMGIPubMedStanford SOURCETreefamUniProtKB
Wikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDK10
CDC HuGE Published Literature: CDK10
Positive Disease Associations: Hair Color , Heart Failure , Melanoma
Related Studies:
  1. Hair Color
    Jiali Han et al. PLoS genetics 2008, A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation., PLoS genetics. [PubMed 18483556]
  2. Heart Failure
    , , . [PubMed 0]
  3. Melanoma
    Jennifer H Barrett et al. Nature genetics 2011, Genome-wide association study identifies three new melanoma susceptibility loci., Nature genetics. [PubMed 21983787]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: CDK10
Diseases sorted by gene-association score: star syndrome (10), tick infestation (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.15 RPKM in Thyroid
Total median expression: 437.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.90183-0.409 Picture PostScript Text
3' UTR -188.20408-0.461 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q59EI2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation


-  Descriptions from all associated GenBank mRNAs
  AK131531 - Homo sapiens cDNA FLJ16760 fis, clone BRACE3050764, highly similar to Cell division protein kinase 10 (EC 2.7.11.22).
AK298386 - Homo sapiens cDNA FLJ59580 complete cds, highly similar to Cell division protein kinase 10 (EC 2.7.11.22).
L33264 - Homo sapiens CDC2-related protein kinase (PISSLRE) mRNA, complete cds.
AK075036 - Homo sapiens cDNA FLJ90555 fis, clone OVARC1000916, highly similar to Cell division protein kinase 10 (EC 2.7.11.22).
AK295397 - Homo sapiens cDNA FLJ53790 complete cds, highly similar to Cell division protein kinase 10 (EC 2.7.11.22).
AB209829 - Homo sapiens mRNA for cyclin-dependent kinase 10 isoform 3 variant protein.
BC017342 - Homo sapiens cyclin-dependent kinase 10, mRNA (cDNA clone MGC:29611 IMAGE:4865641), complete cds.
AK292351 - Homo sapiens cDNA FLJ78380 complete cds, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10, mRNA.
BC093028 - Homo sapiens cDNA clone IMAGE:30528614.
AK296631 - Homo sapiens cDNA FLJ52672 complete cds, highly similar to Cell division protein kinase 10 (EC 2.7.11.22).
AK290485 - Homo sapiens cDNA FLJ75138 complete cds, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10 (CDK10), transcript variant 3, mRNA.
AF153430 - Homo sapiens cyclin-dependent kinase related protein (CDK10) mRNA, splice variant, complete cds.
AK312016 - Homo sapiens cDNA, FLJ92291, highly similar to Homo sapiens cyclin-dependent kinase (CDC2-like) 10 (CDK10), transcript variant 3, mRNA.
BC025301 - Homo sapiens cyclin-dependent kinase 10, mRNA (cDNA clone MGC:39266 IMAGE:4637860), complete cds.
BC032704 - Homo sapiens cDNA clone IMAGE:5247509, with apparent retained intron.
X78342 - H.sapiens PISSLRE mRNA.
CU675952 - Synthetic construct Homo sapiens gateway clone IMAGE:100022382 5' read CDK10 mRNA.
AB462997 - Synthetic construct DNA, clone: pF1KB8433, Homo sapiens CDK10 gene for cyclin-dependent kinase 10, without stop codon, in Flexi system.
AM392903 - Synthetic construct Homo sapiens clone IMAGE:100002691 for hypothetical protein (CDK10 gene).
KJ892561 - Synthetic construct Homo sapiens clone ccsbBroadEn_01955 CDK10 gene, encodes complete protein.
KJ905356 - Synthetic construct Homo sapiens clone ccsbBroadEn_14903 CDK10 gene, encodes complete protein.
AM393177 - Synthetic construct Homo sapiens clone IMAGE:100002937 for hypothetical protein (CDK10 gene).
AM393204 - Synthetic construct Homo sapiens clone IMAGE:100002938 for hypothetical protein (CDK10 gene).
EU832413 - Synthetic construct Homo sapiens clone HAIB:100067442; DKFZo004F0228 cyclin-dependent kinase 10 protein (CDK10) gene, encodes complete protein.
EU832328 - Synthetic construct Homo sapiens clone HAIB:100067357; DKFZo008F0227 cyclin-dependent kinase 10 protein (CDK10) gene, encodes complete protein.
KJ905968 - Synthetic construct Homo sapiens clone ccsbBroadEn_15638 CDK10 gene, encodes complete protein.
JD424052 - Sequence 405076 from Patent EP1572962.
JD540678 - Sequence 521702 from Patent EP1572962.
JD044515 - Sequence 25539 from Patent EP1572962.
JD105151 - Sequence 86175 from Patent EP1572962.
JD237875 - Sequence 218899 from Patent EP1572962.
JD353956 - Sequence 334980 from Patent EP1572962.
LF208351 - JP 2014500723-A/15854: Polycomb-Associated Non-Coding RNAs.
LF375189 - JP 2014500723-A/182692: Polycomb-Associated Non-Coding RNAs.
LF375190 - JP 2014500723-A/182693: Polycomb-Associated Non-Coding RNAs.
LF375191 - JP 2014500723-A/182694: Polycomb-Associated Non-Coding RNAs.
JD292011 - Sequence 273035 from Patent EP1572962.
JD448432 - Sequence 429456 from Patent EP1572962.
LF375192 - JP 2014500723-A/182695: Polycomb-Associated Non-Coding RNAs.
MA443928 - JP 2018138019-A/15854: Polycomb-Associated Non-Coding RNAs.
MA610766 - JP 2018138019-A/182692: Polycomb-Associated Non-Coding RNAs.
MA610767 - JP 2018138019-A/182693: Polycomb-Associated Non-Coding RNAs.
MA610768 - JP 2018138019-A/182694: Polycomb-Associated Non-Coding RNAs.
MA610769 - JP 2018138019-A/182695: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AB209829, Q59EI2, Q59EI2_HUMAN
UCSC ID: uc002fob.2
RefSeq Accession: NR_027703
Protein: Q59EI2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AB209829.1
exon count: 7CDS single in 3' UTR: no RNA size: 2164
ORF size: 558CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 1071.00frame shift in genome: no % Coverage: 52.17
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 581# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.