Human Gene DPEP1 (uc002fns.4) Description and Page Index
Description: Homo sapiens dipeptidase 1 (renal) (DPEP1), transcript variant 2, mRNA. RefSeq Summary (NM_004413): The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]. Transcript (Including UTRs) Position: hg19 chr16:89,696,697-89,704,839 Size: 8,143 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr16:89,696,819-89,704,630 Size: 7,812 Coding Exon Count: 10
ID:DPEP1_HUMAN DESCRIPTION: RecName: Full=Dipeptidase 1; EC=184.108.40.206; AltName: Full=Dehydropeptidase-I; AltName: Full=Microsomal dipeptidase; AltName: Full=Renal dipeptidase; Short=hRDP; Flags: Precursor; FUNCTION: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. CATALYTIC ACTIVITY: Hydrolysis of dipeptides. COFACTOR: Zinc. ENZYME REGULATION: Inhibited by L-penicillamine (By similarity). SUBUNIT: Homodimer; disulfide-linked. INTERACTION: Q96EK5:KIAA1279; NbExp=2; IntAct=EBI-749514, EBI-744150; SUBCELLULAR LOCATION: Apical cell membrane; Lipid-anchor, GPI- anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI- anchor. Note=Brush border membrane. SIMILARITY: Belongs to the peptidase M19 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DPEP1 CDC HuGE Published Literature: DPEP1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16444
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.