Human Gene EMC8 (uc002fjd.3) Description and Page Index
  Description: Homo sapiens ER membrane protein complex subunit 8 (EMC8), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:85,812,231-85,833,148 Size: 20,918 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr16:85,813,314-85,832,901 Size: 19,588 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:85,812,231-85,833,148)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ER membrane protein complex subunit 8; AltName: Full=Neighbor of COX4; AltName: Full=Protein FAM158B;
SUBUNIT: Component of the ER membrane protein complex (EMC).
TISSUE SPECIFICITY: Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.
SIMILARITY: Belongs to the EMC8/EMC9 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.33 RPKM in Testis
Total median expression: 463.30 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -139.30247-0.564 Picture PostScript Text
3' UTR -336.511083-0.311 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005366 - UPF0172

Pfam Domains:
PF03665 - Uncharacterised protein family (UPF0172)

ModBase Predicted Comparative 3D Structure on O43402
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 Protein SequenceProtein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0072546 ER membrane protein complex

-  Descriptions from all associated GenBank mRNAs
  BC001472 - Homo sapiens COX4 neighbor, mRNA (cDNA clone MGC:1371 IMAGE:3138396), complete cds.
BC005886 - Homo sapiens COX4 neighbor, mRNA (cDNA clone MGC:4817 IMAGE:3546377), complete cds.
BC020250 - Homo sapiens COX4 neighbor, mRNA (cDNA clone MGC:32039 IMAGE:4653699), complete cds.
BC007445 - Homo sapiens COX4 neighbor, mRNA (cDNA clone MGC:4522 IMAGE:3009805), complete cds.
JD196008 - Sequence 177032 from Patent EP1572962.
JD247213 - Sequence 228237 from Patent EP1572962.
JD413538 - Sequence 394562 from Patent EP1572962.
JD162070 - Sequence 143094 from Patent EP1572962.
JD427581 - Sequence 408605 from Patent EP1572962.
JD488785 - Sequence 469809 from Patent EP1572962.
JD172473 - Sequence 153497 from Patent EP1572962.
AK057439 - Homo sapiens cDNA FLJ32877 fis, clone TESTI2004089.
AF005888 - Homo sapiens COX4AL mRNA, complete cds.
JD146640 - Sequence 127664 from Patent EP1572962.
BT007132 - Homo sapiens neighbor of COX4 mRNA, complete cds.
AK313977 - Homo sapiens cDNA, FLJ94626, Homo sapiens neighbor of COX4 (NOC4), mRNA.
CU675661 - Synthetic construct Homo sapiens gateway clone IMAGE:100018582 5' read COX4NB mRNA.
JD408842 - Sequence 389866 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C16orf2, C16orf4, COX4AL, COX4NB, EMC8_HUMAN, FAM158B, NM_006067, NOC4, NP_006058, O43402
UCSC ID: uc002fjd.3
RefSeq Accession: NM_006067
Protein: O43402 (aka EMC8_HUMAN)
CCDS: CCDS10954.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_006067.4
exon count: 5CDS single in 3' UTR: no RNA size: 1964
ORF size: 633CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1466.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.