ID:ZDHC7_HUMAN DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC7; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 7; Short=DHHC-7; AltName: Full=Zinc finger protein 370; FUNCTION: Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors. CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Golgi apparatus. DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity). SIMILARITY: Belongs to the DHHC palmitoyltransferase family. SIMILARITY: Contains 1 DHHC-type zinc finger. SEQUENCE CAUTION: Sequence=AAH17702.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ZDHHC7 CDC HuGE Published Literature: ZDHHC7 Positive Disease Associations: height Related Studies:
height Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NXF8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.