Human Gene ZDHHC7 (uc002fiq.2) Description and Page Index
  Description: Homo sapiens zinc finger, DHHC-type containing 7 (ZDHHC7), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:85,008,067-85,045,141 Size: 37,075 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr16:85,009,949-85,024,224 Size: 14,276 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:85,008,067-85,045,141)mRNA (may differ from genome)Protein (308 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZDHC7_HUMAN
DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC7; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 7; Short=DHHC-7; AltName: Full=Zinc finger protein 370;
FUNCTION: Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Golgi apparatus.
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.
SEQUENCE CAUTION: Sequence=AAH17702.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZDHHC7
CDC HuGE Published Literature: ZDHHC7
Positive Disease Associations: height
Related Studies:
  1. height
    Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15. [PubMed 18391951]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.52 RPKM in Bladder
Total median expression: 960.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -162.30353-0.460 Picture PostScript Text
3' UTR -651.821882-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q9NXF8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0018345 protein palmitoylation

Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  FJ423745 - Homo sapiens USP10/ZDHHC7 fusion mRNA, partial sequence.
LF384478 - JP 2014500723-A/191981: Polycomb-Associated Non-Coding RNAs.
AK023428 - Homo sapiens cDNA FLJ13366 fis, clone PLACE1000453.
AK130081 - Homo sapiens cDNA FLJ26571 fis, clone LNF05718.
BC017702 - Homo sapiens zinc finger, DHHC-type containing 7, mRNA (cDNA clone MGC:21134 IMAGE:4394921), complete cds.
AK001654 - Homo sapiens cDNA FLJ10792 fis, clone NT2RP4000560.
AK000286 - Homo sapiens cDNA FLJ20279 fis, clone HEP03229.
JD162167 - Sequence 143191 from Patent EP1572962.
BC018772 - Homo sapiens zinc finger, DHHC-type containing 7, mRNA (cDNA clone MGC:32060 IMAGE:4869114), complete cds.
JD214830 - Sequence 195854 from Patent EP1572962.
JD406229 - Sequence 387253 from Patent EP1572962.
JD130388 - Sequence 111412 from Patent EP1572962.
JD172805 - Sequence 153829 from Patent EP1572962.
JD342972 - Sequence 323996 from Patent EP1572962.
JD469685 - Sequence 450709 from Patent EP1572962.
JD464170 - Sequence 445194 from Patent EP1572962.
JD179016 - Sequence 160040 from Patent EP1572962.
JD160088 - Sequence 141112 from Patent EP1572962.
JD475216 - Sequence 456240 from Patent EP1572962.
JD462750 - Sequence 443774 from Patent EP1572962.
JD085365 - Sequence 66389 from Patent EP1572962.
LF374942 - JP 2014500723-A/182445: Polycomb-Associated Non-Coding RNAs.
JD036959 - Sequence 17983 from Patent EP1572962.
JD506802 - Sequence 487826 from Patent EP1572962.
LF374943 - JP 2014500723-A/182446: Polycomb-Associated Non-Coding RNAs.
JD098210 - Sequence 79234 from Patent EP1572962.
JD453845 - Sequence 434869 from Patent EP1572962.
JD254883 - Sequence 235907 from Patent EP1572962.
JD244554 - Sequence 225578 from Patent EP1572962.
JD252969 - Sequence 233993 from Patent EP1572962.
JD515741 - Sequence 496765 from Patent EP1572962.
JD341681 - Sequence 322705 from Patent EP1572962.
JD563760 - Sequence 544784 from Patent EP1572962.
JD094804 - Sequence 75828 from Patent EP1572962.
LF374944 - JP 2014500723-A/182447: Polycomb-Associated Non-Coding RNAs.
JD206643 - Sequence 187667 from Patent EP1572962.
AK225768 - Homo sapiens mRNA for zinc finger, DHHC domain containing 7 variant, clone: FCC133F01.
JD463679 - Sequence 444703 from Patent EP1572962.
JD478448 - Sequence 459472 from Patent EP1572962.
JD543109 - Sequence 524133 from Patent EP1572962.
CU676028 - Synthetic construct Homo sapiens gateway clone IMAGE:100023256 5' read ZDHHC7 mRNA.
KJ902843 - Synthetic construct Homo sapiens clone ccsbBroadEn_12237 ZDHHC7 gene, encodes complete protein.
KJ899162 - Synthetic construct Homo sapiens clone ccsbBroadEn_08556 ZDHHC7 gene, encodes complete protein.
DQ891968 - Synthetic construct clone IMAGE:100004598; FLH181921.01X; RZPDo839A09138D zinc finger, DHHC-type containing 7 (ZDHHC7) gene, encodes complete protein.
DQ895157 - Synthetic construct Homo sapiens clone IMAGE:100009617; FLH181917.01L; RZPDo839A09137D zinc finger, DHHC-type containing 7 (ZDHHC7) gene, encodes complete protein.
AB464421 - Synthetic construct DNA, clone: pF1KB8282, Homo sapiens ZDHHC7 gene for zinc finger, DHHC-type containing protein 7, without stop codon, in Flexi system.
LF374945 - JP 2014500723-A/182448: Polycomb-Associated Non-Coding RNAs.
CU676326 - Synthetic construct Homo sapiens gateway clone IMAGE:100021961 5' read ZDHHC7 mRNA.
JD020049 - Sequence 1073 from Patent EP1572962.
JD032407 - Sequence 13431 from Patent EP1572962.
JD536047 - Sequence 517071 from Patent EP1572962.
JD200050 - Sequence 181074 from Patent EP1572962.
JD129731 - Sequence 110755 from Patent EP1572962.
JD188437 - Sequence 169461 from Patent EP1572962.
JD129785 - Sequence 110809 from Patent EP1572962.
JD125058 - Sequence 106082 from Patent EP1572962.
JD522793 - Sequence 503817 from Patent EP1572962.
MA620055 - JP 2018138019-A/191981: Polycomb-Associated Non-Coding RNAs.
MA610519 - JP 2018138019-A/182445: Polycomb-Associated Non-Coding RNAs.
MA610520 - JP 2018138019-A/182446: Polycomb-Associated Non-Coding RNAs.
MA610521 - JP 2018138019-A/182447: Polycomb-Associated Non-Coding RNAs.
MA610522 - JP 2018138019-A/182448: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DUM1, NM_017740, NP_060210, Q8WV42, Q9NVD8, Q9NXF8, ZDHC7_HUMAN, ZNF370
UCSC ID: uc002fiq.2
RefSeq Accession: NM_017740
Protein: Q9NXF8 (aka ZDHC7_HUMAN or ZDH7_HUMAN)
CCDS: CCDS10950.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_017740.2
exon count: 8CDS single in 3' UTR: no RNA size: 3168
ORF size: 927CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1581.00frame shift in genome: no % Coverage: 99.81
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 952# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.