Human Gene KCNG4 (uc002fhu.1) Description and Page Index
  Description: Homo sapiens potassium voltage-gated channel, subfamily G, member 4 (KCNG4), mRNA.
RefSeq Summary (NM_172347): Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC109203.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr16:84,269,014-84,273,356 Size: 4,343 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr16:84,270,321-84,271,091 Size: 771 Coding Exon Count: 1 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:84,269,014-84,273,356)mRNA (may differ from genome)Protein (256 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
Stanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KCNG4
CDC HuGE Published Literature: KCNG4
Positive Disease Associations: Lymphocytes , Neutrophils
Related Studies:
  1. Lymphocytes
    , , . [PubMed 0]
  2. Neutrophils
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.20 RPKM in Brain - Amygdala
Total median expression: 1.58 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.14121-0.290 Picture PostScript Text
3' UTR -398.291307-0.305 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF02214 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q8TDN1-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AF348984 - Homo sapiens voltage-gated potassium channel Kv6.3 mRNA, complete cds.
AF450108 - Homo sapiens voltage-gated potassium channel subunit Kv6.3 mRNA, complete cds.
BC109203 - Homo sapiens potassium voltage-gated channel, subfamily G, member 4, mRNA (cDNA clone MGC:129609 IMAGE:40005993), complete cds.
KJ899959 - Synthetic construct Homo sapiens clone ccsbBroadEn_09353 KCNG4 gene, encodes complete protein.
BC008969 - Homo sapiens potassium voltage-gated channel, subfamily G, member 4, mRNA (cDNA clone IMAGE:3028985), complete cds.
JD383424 - Sequence 364448 from Patent EP1572962.
JD062100 - Sequence 43124 from Patent EP1572962.
JD428853 - Sequence 409877 from Patent EP1572962.
JD442013 - Sequence 423037 from Patent EP1572962.
JD329383 - Sequence 310407 from Patent EP1572962.
JD272698 - Sequence 253722 from Patent EP1572962.
JD260899 - Sequence 241923 from Patent EP1572962.
JD527392 - Sequence 508416 from Patent EP1572962.
JD088252 - Sequence 69276 from Patent EP1572962.
JD214220 - Sequence 195244 from Patent EP1572962.
JD188990 - Sequence 170014 from Patent EP1572962.
JD355989 - Sequence 337013 from Patent EP1572962.
JD255693 - Sequence 236717 from Patent EP1572962.
JD502200 - Sequence 483224 from Patent EP1572962.
JD486856 - Sequence 467880 from Patent EP1572962.
JD550806 - Sequence 531830 from Patent EP1572962.
JD405116 - Sequence 386140 from Patent EP1572962.
JD180792 - Sequence 161816 from Patent EP1572962.
JD465216 - Sequence 446240 from Patent EP1572962.
JD132651 - Sequence 113675 from Patent EP1572962.
JD335012 - Sequence 316036 from Patent EP1572962.
JD210798 - Sequence 191822 from Patent EP1572962.
JD111538 - Sequence 92562 from Patent EP1572962.
KJ903596 - Synthetic construct Homo sapiens clone ccsbBroadEn_12990 KCNG4 gene, encodes complete protein.
DQ893254 - Synthetic construct clone IMAGE:100005884; FLH195657.01X; RZPDo839E10152D potassium voltage-gated channel, subfamily G, member 4 (KCNG4) gene, encodes complete protein.
DQ896583 - Synthetic construct Homo sapiens clone IMAGE:100011043; FLH195653.01L; RZPDo839E10151D potassium voltage-gated channel, subfamily G, member 4 (KCNG4) gene, encodes complete protein.
JD336672 - Sequence 317696 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TDN1 (Reactome details) participates in the following event(s):

R-HSA-1296127 Activation of voltage gated Potassium channels
R-HSA-1296072 Voltage gated Potassium channels
R-HSA-1296071 Potassium Channels
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: BC008969, KCNG3, NM_172347, NP_758857, Q8TDN1-2
UCSC ID: uc002fhu.1
RefSeq Accession: NM_172347
Protein: Q8TDN1-2, splice isoform of Q8TDN1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC008969.2
exon count: 2CDS single in 3' UTR: no RNA size: 2234
ORF size: 771CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1676.00frame shift in genome: no % Coverage: 98.43
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1322# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.