Human Gene IST1 (uc002fbk.2) Description and Page Index
  Description: Homo sapiens increased sodium tolerance 1 homolog (yeast) (IST1), transcript variant 2, mRNA.
RefSeq Summary (NM_014761): This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
Transcript (Including UTRs)
   Position: hg19 chr16:71,929,396-71,964,540 Size: 35,145 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr16:71,949,544-71,961,702 Size: 12,159 Coding Exon Count: 9 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:71,929,396-71,964,540)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIOMIM
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.37 RPKM in Pituitary
Total median expression: 1929.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.70112-0.390 Picture PostScript Text
3' UTR -910.322838-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF03398 - Regulator of Vps4 activity in the MVB pathway

ModBase Predicted Comparative 3D Structure on P53990-3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGD  WormBaseSGD
 Protein Sequence  Protein SequenceProtein Sequence
 Alignment  AlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  AK057258 - Homo sapiens cDNA FLJ32696 fis, clone TESTI2000358.
AK293040 - Homo sapiens cDNA FLJ77725 complete cds.
AK291388 - Homo sapiens cDNA FLJ78449 complete cds.
AK297336 - Homo sapiens cDNA FLJ52563 complete cds.
BC103745 - Homo sapiens KIAA0174, mRNA (cDNA clone MGC:117220 IMAGE:6009274), complete cds.
AK301918 - Homo sapiens cDNA FLJ59095 complete cds.
AK293022 - Homo sapiens cDNA FLJ78415 complete cds.
AK297088 - Homo sapiens cDNA FLJ52560 complete cds.
AK057902 - Homo sapiens cDNA FLJ25173 fis, clone CBR08822.
AB097052 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM28.
D79996 - Homo sapiens KIAA0174 mRNA, partial cds.
BC000430 - Homo sapiens KIAA0174, mRNA (cDNA clone MGC:8358 IMAGE:2819828), complete cds.
BC004359 - Homo sapiens KIAA0174, mRNA (cDNA clone MGC:4312 IMAGE:2819828), complete cds.
BC000116 - Homo sapiens KIAA0174, mRNA (cDNA clone MGC:3110 IMAGE:3350789), complete cds.
CU674216 - Synthetic construct Homo sapiens gateway clone IMAGE:100017102 5' read KIAA0174 mRNA.
HQ447682 - Synthetic construct Homo sapiens clone IMAGE:100071701; CCSB003143_01 KIAA0174 (KIAA0174) gene, encodes complete protein.
KJ892851 - Synthetic construct Homo sapiens clone ccsbBroadEn_02245 IST1 gene, encodes complete protein.
KJ902023 - Synthetic construct Homo sapiens clone ccsbBroadEn_11417 IST1 gene, encodes complete protein.
AB383784 - Synthetic construct DNA, clone: pF1KSDA0174, Homo sapiens KIAA0174 gene for KIAA0174 protein, complete cds, without stop codon, in Flexi system.
AK295066 - Homo sapiens cDNA FLJ52541 complete cds.
JD203204 - Sequence 184228 from Patent EP1572962.
CU674046 - Synthetic construct Homo sapiens gateway clone IMAGE:100018987 5' read KIAA0174 mRNA.
DQ587024 - Homo sapiens piRNA piR-54136, complete sequence.
DQ590325 - Homo sapiens piRNA piR-57437, complete sequence.
AL355695 - Homo sapiens EST from clone 114069, full insert.
LF374504 - JP 2014500723-A/182007: Polycomb-Associated Non-Coding RNAs.
LF374502 - JP 2014500723-A/182005: Polycomb-Associated Non-Coding RNAs.
JD530163 - Sequence 511187 from Patent EP1572962.
JD503687 - Sequence 484711 from Patent EP1572962.
JD132296 - Sequence 113320 from Patent EP1572962.
JD251301 - Sequence 232325 from Patent EP1572962.
LF374501 - JP 2014500723-A/182004: Polycomb-Associated Non-Coding RNAs.
JD420817 - Sequence 401841 from Patent EP1572962.
JD400845 - Sequence 381869 from Patent EP1572962.
LF374500 - JP 2014500723-A/182003: Polycomb-Associated Non-Coding RNAs.
JD340622 - Sequence 321646 from Patent EP1572962.
JD111451 - Sequence 92475 from Patent EP1572962.
JD344556 - Sequence 325580 from Patent EP1572962.
JD482503 - Sequence 463527 from Patent EP1572962.
JD075363 - Sequence 56387 from Patent EP1572962.
JD450427 - Sequence 431451 from Patent EP1572962.
DQ591076 - Homo sapiens piRNA piR-58188, complete sequence.
JD557708 - Sequence 538732 from Patent EP1572962.
JD225811 - Sequence 206835 from Patent EP1572962.
JD433909 - Sequence 414933 from Patent EP1572962.
JD302109 - Sequence 283133 from Patent EP1572962.
JD307716 - Sequence 288740 from Patent EP1572962.
JD274205 - Sequence 255229 from Patent EP1572962.
JD492853 - Sequence 473877 from Patent EP1572962.
JD237430 - Sequence 218454 from Patent EP1572962.
BC038350 - Homo sapiens cDNA clone IMAGE:4537875, with apparent retained intron.
LF384451 - JP 2014500723-A/191954: Polycomb-Associated Non-Coding RNAs.
MA620028 - JP 2018138019-A/191954: Polycomb-Associated Non-Coding RNAs.
MA610081 - JP 2018138019-A/182007: Polycomb-Associated Non-Coding RNAs.
MA610079 - JP 2018138019-A/182005: Polycomb-Associated Non-Coding RNAs.
MA610078 - JP 2018138019-A/182004: Polycomb-Associated Non-Coding RNAs.
MA610077 - JP 2018138019-A/182003: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P53990 (Reactome details) participates in the following event(s):

R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0174, NM_014761, NP_055576, P53990-3, uc002fbk.1
UCSC ID: uc002fbk.2
RefSeq Accession: NM_014761
Protein: P53990-3, splice isoform of P53990 CCDS: CCDS10905.1, CCDS59272.1, CCDS59271.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014761.3
exon count: 10CDS single in 3' UTR: no RNA size: 4035
ORF size: 1083CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2287.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.