Human Gene ZNF821 (uc002fbh.4) Description and Page Index
  Description: Homo sapiens zinc finger protein 821 (ZNF821), transcript variant 3, mRNA.
RefSeq Summary (NM_001201554): This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Transcript (Including UTRs)
   Position: hg19 chr16:71,893,583-71,918,093 Size: 24,511 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr16:71,893,921-71,913,849 Size: 19,929 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:71,893,583-71,918,093)mRNA (may differ from genome)Protein (370 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN821_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 821;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 2 C2H2-type zinc fingers.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF821
CDC HuGE Published Literature: ZNF821

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.20 RPKM in Testis
Total median expression: 281.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -191.50423-0.453 Picture PostScript Text
3' UTR -122.90338-0.364 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on O75541
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF208308 - JP 2014500723-A/15811: Polycomb-Associated Non-Coding RNAs.
BC004563 - Homo sapiens hypothetical protein LOC55565, mRNA (cDNA clone IMAGE:4053325), partial cds.
BC091492 - Homo sapiens zinc finger protein 821, mRNA (cDNA clone IMAGE:30387263), with apparent retained intron.
AF070588 - Homo sapiens clone 24554 unknown mRNA.
BC012116 - Homo sapiens zinc finger protein 821, mRNA (cDNA clone MGC:20131 IMAGE:4553333), complete cds.
JD062059 - Sequence 43083 from Patent EP1572962.
JD068637 - Sequence 49661 from Patent EP1572962.
JD362135 - Sequence 343159 from Patent EP1572962.
JD212250 - Sequence 193274 from Patent EP1572962.
AK296603 - Homo sapiens cDNA FLJ57016 complete cds.
JD317993 - Sequence 299017 from Patent EP1572962.
JD365370 - Sequence 346394 from Patent EP1572962.
JD475895 - Sequence 456919 from Patent EP1572962.
JD130373 - Sequence 111397 from Patent EP1572962.
JD419242 - Sequence 400266 from Patent EP1572962.
AK313693 - Homo sapiens cDNA, FLJ94283.
HQ447826 - Synthetic construct Homo sapiens clone IMAGE:100071169; CCSB007117_01 hypothetical protein LOC55565 (ZNF821) gene, encodes complete protein.
KJ899150 - Synthetic construct Homo sapiens clone ccsbBroadEn_08544 ZNF821-like gene, encodes complete protein.
AB527767 - Synthetic construct DNA, clone: pF1KB5819, Homo sapiens ZNF821 gene for zinc finger protein 821, without stop codon, in Flexi system.
CU680220 - Synthetic construct Homo sapiens gateway clone IMAGE:100019114 5' read LOC55565 mRNA.
LF374513 - JP 2014500723-A/182016: Polycomb-Associated Non-Coding RNAs.
DQ586295 - Homo sapiens piRNA piR-53407, complete sequence.
AK131336 - Homo sapiens cDNA FLJ16350 fis, clone TESTI2037830.
LF374512 - JP 2014500723-A/182015: Polycomb-Associated Non-Coding RNAs.
JD434701 - Sequence 415725 from Patent EP1572962.
MA443885 - JP 2018138019-A/15811: Polycomb-Associated Non-Coding RNAs.
MA610090 - JP 2018138019-A/182016: Polycomb-Associated Non-Coding RNAs.
MA610089 - JP 2018138019-A/182015: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NK48, B4DKK4, D3DWS3, NM_001201554, NP_060000, O75541, ZN821_HUMAN
UCSC ID: uc002fbh.4
RefSeq Accession: NM_001201554
Protein: O75541 (aka ZN821_HUMAN)
CCDS: CCDS32481.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001201554.1
exon count: 7CDS single in 3' UTR: no RNA size: 1894
ORF size: 1113CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2426.00frame shift in genome: no % Coverage: 98.94
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.