Human Gene PHLPP2 (uc002fay.1) Description and Page Index
  Description: Homo sapiens PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:71,711,377-71,757,715 Size: 46,339 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr16:71,712,654-71,748,698 Size: 36,045 Coding Exon Count: 7 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:71,711,377-71,757,715)mRNA (may differ from genome)Protein (423 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCEWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PHLPP2
CDC HuGE Published Literature: PHLPP2

-  MalaCards Disease Associations
  MalaCards Gene Search: PHLPP2
Diseases sorted by gene-association score: colorectal cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.26 RPKM in Small Intestine - Terminal Ileum
Total median expression: 146.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.0050-0.320 Picture PostScript Text
3' UTR -343.071277-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  BC035267 - Homo sapiens PH domain and leucine rich repeat protein phosphatase-like, mRNA (cDNA clone IMAGE:4828359), partial cds.
LP896041 - Sequence 905 from Patent EP3253886.
AB023148 - Homo sapiens KIAA0931 mRNA for KIAA0931 protein, complete cds.
BX647823 - Homo sapiens mRNA; cDNA DKFZp686F0186 (from clone DKFZp686F0186).
BX648157 - Homo sapiens mRNA; cDNA DKFZp686A2432 (from clone DKFZp686A2432).
BC129927 - Homo sapiens PH domain and leucine rich repeat protein phosphatase-like, mRNA (cDNA clone MGC:150693 IMAGE:40124720), complete cds.
BC129983 - Homo sapiens PH domain and leucine rich repeat protein phosphatase-like, mRNA (cDNA clone IMAGE:40124721), complete cds.
AM393067 - Synthetic construct Homo sapiens clone IMAGE:100002343 for hypothetical protein (PHLPPL gene).
AM393542 - Synthetic construct Homo sapiens clone IMAGE:100002342 for hypothetical protein (PHLPPL gene).
AB463166 - Synthetic construct DNA, clone: pF1KA0931, Homo sapiens PHLPPL gene for PH domain and leucine rich repeat protein phosphatase-like, without stop codon, in Flexi system.
AK124678 - Homo sapiens cDNA FLJ42687 fis, clone BRAMY3001794, moderately similar to Rattus norvegicus SCN circadian oscillatory protein (Scop).
JD095783 - Sequence 76807 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK124678, NM_015020, NP_055835
UCSC ID: uc002fay.1
RefSeq Accession: NM_015020

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK124678.1
exon count: 8CDS single in 3' UTR: no RNA size: 3467
ORF size: 1272CDS single in intron: no Alignment % ID: 99.54
txCdsPredict score: 2744.00frame shift in genome: no % Coverage: 74.94
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1281# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.