Human Gene ANGEL2 (uc001hjz.3) Description and Page Index
  Description: Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:213,165,524-213,189,168 Size: 23,645 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr1:213,168,383-213,189,013 Size: 20,631 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:213,165,524-213,189,168)mRNA (may differ from genome)Protein (544 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein angel homolog 2;
SIMILARITY: Belongs to the CCR4/nocturin family.
SEQUENCE CAUTION: Sequence=AAH47469.1; Type=Erroneous termination; Positions=456; Note=Translated as Ser;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.55 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 241.06 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.60155-0.346 Picture PostScript Text
3' UTR -789.732859-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005135 - Endo/exonuclease/phosphatase

Pfam Domains:
PF03372 - Endonuclease/Exonuclease/phosphatase family

SCOP Domains:
56219 - DNase I-like

ModBase Predicted Comparative 3D Structure on Q5VTE6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003730 mRNA 3'-UTR binding

Biological Process:
GO:0045930 negative regulation of mitotic cell cycle
GO:0070935 3'-UTR-mediated mRNA stabilization

Cellular Component:
GO:0005737 cytoplasm
GO:0015030 Cajal body

-  Descriptions from all associated GenBank mRNAs
  BC047469 - Homo sapiens angel homolog 2 (Drosophila), mRNA (cDNA clone MGC:48353 IMAGE:5274835), complete cds.
AK022855 - Homo sapiens cDNA FLJ12793 fis, clone NT2RP2002033.
JD369221 - Sequence 350245 from Patent EP1572962.
JD384766 - Sequence 365790 from Patent EP1572962.
AF510741 - Homo sapiens chromosome 1 unknown mRNA.
JD311984 - Sequence 293008 from Patent EP1572962.
JD308040 - Sequence 289064 from Patent EP1572962.
JD435362 - Sequence 416386 from Patent EP1572962.
JD435363 - Sequence 416387 from Patent EP1572962.
JD308041 - Sequence 289065 from Patent EP1572962.
JD218504 - Sequence 199528 from Patent EP1572962.
JD522077 - Sequence 503101 from Patent EP1572962.
JD514196 - Sequence 495220 from Patent EP1572962.
JD514195 - Sequence 495219 from Patent EP1572962.
JD514197 - Sequence 495221 from Patent EP1572962.
AK093947 - Homo sapiens cDNA FLJ36628 fis, clone TRACH2017980.
AL079275 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 566443.
AK295116 - Homo sapiens cDNA FLJ56435 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
AK299208 - Homo sapiens cDNA FLJ50627 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
AK310946 - Homo sapiens cDNA, FLJ17988.
AK294479 - Homo sapiens cDNA FLJ50488 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
AK299365 - Homo sapiens cDNA FLJ50631 complete cds, highly similar to Homo sapiens angel homolog 2 (Drosophila) (ANGEL2), mRNA.
CU690426 - Synthetic construct Homo sapiens gateway clone IMAGE:100020832 5' read ANGEL2 mRNA.
KJ903551 - Synthetic construct Homo sapiens clone ccsbBroadEn_12945 ANGEL2 gene, encodes complete protein.
AK311276 - Homo sapiens cDNA, FLJ18318.
BC016966 - Homo sapiens angel homolog 2 (Drosophila), mRNA (cDNA clone IMAGE:4403747), complete cds.
AY468376 - Homo sapiens LOC90806-like mRNA, complete sequence.
KJ903550 - Synthetic construct Homo sapiens clone ccsbBroadEn_12944 ANGEL2 gene, encodes complete protein.
JD026137 - Sequence 7161 from Patent EP1572962.
JD034817 - Sequence 15841 from Patent EP1572962.
LF205513 - JP 2014500723-A/13016: Polycomb-Associated Non-Coding RNAs.
LF321402 - JP 2014500723-A/128905: Polycomb-Associated Non-Coding RNAs.
MA556979 - JP 2018138019-A/128905: Polycomb-Associated Non-Coding RNAs.
MA441090 - JP 2018138019-A/13016: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ANGE2_HUMAN, B7Z2U4, D3DTA3, KIAA0759L, NM_144567, NP_653168, Q5VTE6, Q86X13, Q8NHH3
UCSC ID: uc001hjz.3
RefSeq Accession: NM_144567
Protein: Q5VTE6 (aka ANGE2_HUMAN)
CCDS: CCDS1512.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_144567.3
exon count: 9CDS single in 3' UTR: no RNA size: 4668
ORF size: 1635CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3319.00frame shift in genome: no % Coverage: 99.59
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.