Human Gene ATF3 (uc001hjj.3) Description and Page Index
  Description: Homo sapiens activating transcription factor 3 (ATF3), transcript variant 4, mRNA.
RefSeq Summary (NM_001674): This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011].
Transcript (Including UTRs)
   Position: hg19 chr1:212,781,970-212,792,589 Size: 10,620 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:212,788,364-212,791,591 Size: 3,228 Coding Exon Count: 2 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:212,781,970-212,792,589)mRNA (may differ from genome)Protein (120 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ATF3
CDC HuGE Published Literature: ATF3

-  MalaCards Disease Associations
  MalaCards Gene Search: ATF3
Diseases sorted by gene-association score: hypospadias (12), bone cancer (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.58 RPKM in Adipose - Visceral (Omentum)
Total median expression: 524.25 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -121.40307-0.395 Picture PostScript Text
3' UTR -349.30998-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR000837 - Leuzip_Fos

Pfam Domains:
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors

ModBase Predicted Comparative 3D Structure on Q7Z567
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
JA482093 - Sequence 76 from Patent WO2011072091.
JB251942 - Sequence 9 from Patent EP2440214.
JE980385 - Sequence 76 from Patent EP2862929.
LP764841 - Sequence 9 from Patent EP3276004.
HH837080 - Sequence 7 from Patent EP2231168.
HI214721 - Sequence 7 from Patent EP2076526.
HV601523 - JP 2011500003-A/7: Novel siRNA Structures.
HV856596 - JP 2010507387-A/7: Novel siRNAs and Methods of Use Thereof.
HW165083 - JP 2013102767-A/7: Novel siRNA's and Use Thereof.
HW675591 - JP 2014210789-A/7: Novel siRNA Structures.
HW835279 - JP 2015051004-A/7: Novel siRNA's and Use Thereof.
JA538122 - Sequence 7 from Patent EP2371958.
LF211779 - JP 2014500723-A/19282: Polycomb-Associated Non-Coding RNAs.
HH837081 - Sequence 8 from Patent EP2231168.
HH837082 - Sequence 9 from Patent EP2231168.
HI214722 - Sequence 8 from Patent EP2076526.
HI214723 - Sequence 9 from Patent EP2076526.
HV601524 - JP 2011500003-A/8: Novel siRNA Structures.
HV601525 - JP 2011500003-A/9: Novel siRNA Structures.
HV856597 - JP 2010507387-A/8: Novel siRNAs and Methods of Use Thereof.
HV856598 - JP 2010507387-A/9: Novel siRNAs and Methods of Use Thereof.
HW165084 - JP 2013102767-A/8: Novel siRNA's and Use Thereof.
HW165085 - JP 2013102767-A/9: Novel siRNA's and Use Thereof.
HW675592 - JP 2014210789-A/8: Novel siRNA Structures.
HW675593 - JP 2014210789-A/9: Novel siRNA Structures.
HW835280 - JP 2015051004-A/8: Novel siRNA's and Use Thereof.
HW835281 - JP 2015051004-A/9: Novel siRNA's and Use Thereof.
JA482092 - Sequence 75 from Patent WO2011072091.
JA482094 - Sequence 77 from Patent WO2011072091.
JA538123 - Sequence 8 from Patent EP2371958.
JA538124 - Sequence 9 from Patent EP2371958.
JB251943 - Sequence 10 from Patent EP2440214.
JB251944 - Sequence 11 from Patent EP2440214.
JE980384 - Sequence 75 from Patent EP2862929.
JE980386 - Sequence 77 from Patent EP2862929.
LP764842 - Sequence 10 from Patent EP3276004.
LP764843 - Sequence 11 from Patent EP3276004.
LF205515 - JP 2014500723-A/13018: Polycomb-Associated Non-Coding RNAs.
LF213847 - JP 2014500723-A/21350: Polycomb-Associated Non-Coding RNAs.
AK294296 - Homo sapiens cDNA FLJ57271 complete cds, highly similar to Cyclic AMP-dependent transcription factorATF-3.
AK312998 - Homo sapiens cDNA, FLJ93461, Homo sapiens activating transcription factor 3 (ATF3), mRNA.
BC006322 - Homo sapiens activating transcription factor 3, mRNA (cDNA clone MGC:12746 IMAGE:4138076), complete cds.
JD187061 - Sequence 168085 from Patent EP1572962.
L19871 - Human activating transcription factor 3 (ATF3) mRNA, complete cds.
LQ878887 - Sequence 2 from Patent WO2018154075.
AB066566 - Homo sapiens ATF3 mRNA for activating transcription factor 3 delta Zip2, complete cds.
AY313926 - Homo sapiens activating transcription factor 3 delta Zip3 (ATF3) mRNA, complete cds, alternatively spliced.
AY313927 - Homo sapiens activating transcription factor 3 delta Zip2c (ATF3) mRNA, complete cds, alternatively spliced.
AB528347 - Synthetic construct DNA, clone: pF1KB7921, Homo sapiens ATF3 gene for activating transcription factor 3, without stop codon, in Flexi system.
CR450334 - Homo sapiens full open reading frame cDNA clone RZPDo834A122D for gene ATF3, activating transcription factor 3; complete cds; without stopcodon.
DQ895972 - Synthetic construct Homo sapiens clone IMAGE:100010432; FLH189117.01L; RZPDo839B1064D activating transcription factor 3 (ATF3) gene, encodes complete protein.
BT006996 - Homo sapiens activating transcription factor 3 mRNA, complete cds.
DQ892723 - Synthetic construct clone IMAGE:100005353; FLH189121.01X; RZPDo839B1074D activating transcription factor 3 (ATF3) gene, encodes complete protein.
AB078026 - Homo sapiens ATF3deltaZip2a mRNA for ATF3deltaZip2, complete cds.
AB078027 - Homo sapiens ATF3deltaZip2b mRNA for ATF3deltaZip2, complete cds.
KJ896469 - Synthetic construct Homo sapiens clone ccsbBroadEn_05863 ATF3 gene, encodes complete protein.
AB209032 - Homo sapiens mRNA for activating transcription factor 3 long isoform variant protein.
AK123699 - Homo sapiens cDNA FLJ41705 fis, clone HLUNG2009729.
LF321417 - JP 2014500723-A/128920: Polycomb-Associated Non-Coding RNAs.
AB078028 - Homo sapiens ATF3deltaZip2exonD'DE'E mRNA for ATF3deltaZip2, partial cds.
JD042660 - Sequence 23684 from Patent EP1572962.
JD410223 - Sequence 391247 from Patent EP1572962.
MA556994 - JP 2018138019-A/128920: Polycomb-Associated Non-Coding RNAs.
MA447356 - JP 2018138019-A/19282: Polycomb-Associated Non-Coding RNAs.
MA441092 - JP 2018138019-A/13018: Polycomb-Associated Non-Coding RNAs.
MA449424 - JP 2018138019-A/21350: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK294296, NM_001674, NP_001665, Q7Z567, Q7Z567_HUMAN
UCSC ID: uc001hjj.3
RefSeq Accession: NM_001674
Protein: Q7Z567

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK294296.1
exon count: 3CDS single in 3' UTR: no RNA size: 945
ORF size: 363CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 733.00frame shift in genome: no % Coverage: 99.89
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 1013# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.