Human Gene NEK2 (uc001hit.2) Description and Page Index
  Description: Homo sapiens NIMA-related kinase 2 (NEK2), transcript variant 3, mRNA.
RefSeq Summary (NM_001204182): This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: hg19 chr1:211,842,455-211,848,972 Size: 6,518 Total Exon Count: 6 Strand: -


Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesGeneReviewsModel Information
Methods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:211,842,455-211,848,972)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerH-INVHGNCHuman Cortex Gene Expression
LynxPubMedStanford SOURCETreefamWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NEK2
CDC HuGE Published Literature: NEK2

-  MalaCards Disease Associations
  MalaCards Gene Search: NEK2
Diseases sorted by gene-association score: retinitis pigmentosa 67* (969), nek-related retinitis pigmentosa* (500), retinitis pigmentosa* (43), plexiform neurofibroma (13), van der woude syndrome (7), neurofibroma (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.97 RPKM in Testis
Total median expression: 49.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK225522 - Homo sapiens mRNA for NIMA-related kinase 2 variant, clone: KAT06621.
BC043502 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 2, mRNA (cDNA clone MGC:49922 IMAGE:5541026), complete cds.
AY863109 - Homo sapiens never in mitosis gene a-related kinase 2A splice variant NEK2A-T (NEK2A) mRNA, partial cds, alternatively spliced.
U11050 - Human NIMA-like protein kinase 1 (NLK1) mRNA, complete cds.
Z29066 - H.sapiens nek2 mRNA for protein kinase.
AK223353 - Homo sapiens mRNA for NIMA (never in mitosis gene a)-related kinase 2 variant, clone: TST08743.
AK303092 - Homo sapiens cDNA FLJ53945 complete cds, highly similar to Serine/threonine-protein kinase Nek2 (EC 2.7.11.1).
BT019729 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 2 mRNA, complete cds.
AB527570 - Synthetic construct DNA, clone: pF1KB6648, Homo sapiens NEK2 gene for NIMA (never in mitosis gene a)-related kinase 2, without stop codon, in Flexi system.
AY045701 - Homo sapiens NEK2B protein kinase (NEK2) mRNA, complete cds, alternatively spliced.
BC052807 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 2, mRNA (cDNA clone IMAGE:5416586), partial cds.
BC065932 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 2, mRNA (cDNA clone IMAGE:6156703), complete cds.
KJ901600 - Synthetic construct Homo sapiens clone ccsbBroadEn_10994 NEK2 gene, encodes complete protein.
KJ905236 - Synthetic construct Homo sapiens clone ccsbBroadEn_14710 NEK2 gene, encodes complete protein.
CU688108 - Synthetic construct Homo sapiens gateway clone IMAGE:100022787 5' read NEK2 mRNA.
Z25425 - H.sapiens protein-serine/threonine kinase gene, complete CDS.
LF205519 - JP 2014500723-A/13022: Polycomb-Associated Non-Coding RNAs.
LF321453 - JP 2014500723-A/128956: Polycomb-Associated Non-Coding RNAs.
JD485223 - Sequence 466247 from Patent EP1572962.
JD409137 - Sequence 390161 from Patent EP1572962.
MA557030 - JP 2018138019-A/128956: Polycomb-Associated Non-Coding RNAs.
MA441096 - JP 2018138019-A/13022: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC065932
UCSC ID: uc001hit.2
RefSeq Accession: NM_001204182

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene NEK2:
rp-overview (Nonsyndromic Retinitis Pigmentosa Overview)

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: BC065932.1
exon count: 6CDS single in 3' UTR: no RNA size: 1019
ORF size: 0CDS single in intron: no Alignment % ID: 99.90
txCdsPredict score: 1090.00frame shift in genome: no % Coverage: 99.31
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.