Human Gene ZNF644 (uc001dnx.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 2, mRNA.
RefSeq Summary (NM_032186): The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Transcript (Including UTRs)
   Position: hg19 chr1:91,380,857-91,487,812 Size: 106,956 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:91,382,355-91,447,888 Size: 65,534 Coding Exon Count: 3 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:91,380,857-91,487,812)mRNA (may differ from genome)Protein (105 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF644
Diseases sorted by gene-association score: myopia 21, autosomal dominant* (1231), myopia (25), refractive error (18), degenerative myopia (16), spermatocele (12), eye degenerative disease (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.29 RPKM in Nerve - Tibial
Total median expression: 221.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -145.10305-0.476 Picture PostScript Text
3' UTR -325.641498-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9H582-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AB033047 - Homo sapiens mRNA for KIAA1221 protein, partial cds.
BC050656 - Homo sapiens zinc finger protein 644, mRNA (cDNA clone IMAGE:6143167), complete cds.
BC150177 - Homo sapiens zinc finger protein 644, mRNA (cDNA clone MGC:164892 IMAGE:40148078), complete cds.
AK001587 - Homo sapiens cDNA FLJ10725 fis, clone NT2RP3001214.
JD359600 - Sequence 340624 from Patent EP1572962.
JD491499 - Sequence 472523 from Patent EP1572962.
BC132778 - Homo sapiens zinc finger protein 644, mRNA (cDNA clone MGC:164409 IMAGE:40146800), complete cds.
BC132776 - Homo sapiens zinc finger protein 644, mRNA (cDNA clone MGC:164407 IMAGE:40146798), complete cds.
BC063683 - Homo sapiens zinc finger protein 644, mRNA (cDNA clone IMAGE:4396136), partial cds.
AK023596 - Homo sapiens cDNA FLJ13534 fis, clone PLACE1006445.
JD062104 - Sequence 43128 from Patent EP1572962.
BC031003 - Homo sapiens zinc finger protein 644, mRNA (cDNA clone IMAGE:4043043), partial cds.
JD247244 - Sequence 228268 from Patent EP1572962.
JD043072 - Sequence 24096 from Patent EP1572962.
JD166406 - Sequence 147430 from Patent EP1572962.
JD564556 - Sequence 545580 from Patent EP1572962.
JD182032 - Sequence 163056 from Patent EP1572962.
BC041138 - Homo sapiens cDNA clone IMAGE:5588399, containing frame-shift errors.
JD089765 - Sequence 70789 from Patent EP1572962.
AK291520 - Homo sapiens cDNA FLJ76561 complete cds, highly similar to Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 2, mRNA.
JD485259 - Sequence 466283 from Patent EP1572962.
KJ899757 - Synthetic construct Homo sapiens clone ccsbBroadEn_09151 ZNF644 gene, encodes complete protein.
AB384584 - Synthetic construct DNA, clone: pF1KA1221, Homo sapiens ZNF644 gene for zinc finger protein 644, complete cds, without stop codon, in Flexi system.
AB019255 - Homo sapiens mRNA for Zinc finger motif Enhancer binding Protein-2, complete cds.
BC092462 - Homo sapiens zinc finger protein 644, mRNA (cDNA clone IMAGE:30334773), partial cds.
AK024026 - Homo sapiens cDNA FLJ13964 fis, clone Y79AA1001312, weakly similar to ZINC FINGER PROTEIN MLZ-4.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1221, NM_032186, NP_115562, Q9H582-3, ZEP2
UCSC ID: uc001dnx.3
RefSeq Accession: NM_032186
Protein: Q9H582-3, splice isoform of Q9H582 CCDS: CCDS732.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032186.4
exon count: 4CDS single in 3' UTR: no RNA size: 2132
ORF size: 318CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 825.00frame shift in genome: no % Coverage: 99.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.