Human Gene PTPRZ1 (ENST00000651842.1) from GENCODE V41
  Description: protein tyrosine phosphatase, receptor type Z1 (from HGNC PTPRZ1)
RefSeq Summary (NM_002851): This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
Gencode Transcript: ENST00000651842.1
Gencode Gene: ENSG00000106278.12
Transcript (Including UTRs)
   Position: hg38 chr7:121,873,166-122,061,828 Size: 188,663 Total Exon Count: 32 Strand: +
Coding Region
   Position: hg38 chr7:121,873,500-122,061,220 Size: 187,721 Coding Exon Count: 32 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2022-05-14 18:57:26

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:121,873,166-122,061,828)mRNA (may differ from genome)Protein (1908 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold

-  MalaCards Disease Associations
  MalaCards Gene Search: PTPRZ1
Diseases sorted by gene-association score: h. pylori infection* (35), hyperlysinemia (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.69 RPKM in Brain - Amygdala
Total median expression: 386.46 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -94.30334-0.282 Picture PostScript Text
3' UTR -126.50608-0.208 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  JA482198 - Sequence 181 from Patent WO2011072091.
JE980490 - Sequence 181 from Patent EP2862929.
U88967 - Human tyrosine phosphatase zeta polypeptide 2 (HTPZP2) mRNA, partial cds.
M93426 - Human protein tyrosine phosphatase zeta-polypeptide (PTPRZ) mRNA, complete cds.
BC131736 - Homo sapiens cDNA clone IMAGE:40125636, containing frame-shift errors.
BC172407 - Synthetic construct Homo sapiens clone IMAGE:100069101, MGC:199112 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) mRNA, encodes complete protein.
AK294062 - Homo sapiens cDNA FLJ53311 complete cds, highly similar to Receptor-type tyrosine-protein phosphatase zeta precursor (EC
X54135 - Human HPTP zeta mRNA for protein tyrosine phosphatase zeta.
JD114203 - Sequence 95227 from Patent EP1572962.
JD363544 - Sequence 344568 from Patent EP1572962.
JD084008 - Sequence 65032 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05120 - Epithelial cell signaling in Helicobacter pylori infection

-  Other Names for This Gene
  Alternate Gene Symbols: A0A494C1B4, JA482198, uc287hyj.1
UCSC ID: ENST00000651842.1
RefSeq Accession: NM_002851

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.