Human Gene SLC1A2 (ENST00000645194.1) Description and Page Index
Description: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. (from UniProt P43004) RefSeq Summary (NM_001195728): This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]. Gencode Transcript: ENST00000645194.1 Gencode Gene: ENSG00000110436.13 Transcript (Including UTRs) Position: hg38 chr11:35,259,837-35,418,409 Size: 158,573 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr11:35,260,894-35,317,506 Size: 56,613 Coding Exon Count: 10
ID:EAA2_HUMAN DESCRIPTION: RecName: Full=Excitatory amino acid transporter 2; AltName: Full=Glutamate/aspartate transporter II; AltName: Full=Sodium-dependent glutamate/aspartate transporter 2; AltName: Full=Solute carrier family 1 member 2; FUNCTION: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. SUBUNIT: Homotrimer. Interacts with AJUBA (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. PTM: Glycosylated. PTM: Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity (By similarity). SIMILARITY: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A2 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00375 - Sodium:dicarboxylate symporter family
ModBase Predicted Comparative 3D Structure on P43004
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.